STX17 and CDH1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		STX17	CDH1
Description		syntaxin 17	cadherin 1
Image
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Smooth Endoplasmic Reticulum Membrane HOPS Complex SNARE Complex Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Autolysosome Membrane	Extracellular Region Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding
	Biological Process	Intracellular Protein Transport Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Autophagy Golgi Organization Vesicle-mediated Transport Autophagosome Membrane Docking Protein Localization To Phagophore Assembly Site Vesicle Docking Autophagosome-lysosome Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Autophagosome Maturation	Cell Morphogenesis Desmosome Assembly Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Neuron Projection Development Cell Junction Assembly Adherens Junction Organization Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of DNA-templated Transcription Regulation Of Transport Cellular Response To Lithium Ion Response To Heparin Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Response To Gram-positive Bacterium Positive Regulation Of Protein Localization
Pathways		COPII-mediated vesicle transport	Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs
Diseases			Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Alopecia areata ( 20596022) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)	Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428 32341527) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Nevus count or cutaneous melanoma ( 32341527) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Ulcerative colitis ( 19915572)
Interacting Genes		22 interacting genes: AURKA BUB1 CDH1 CTNNA1 DLC1 EGFR KRAS MAP2K4 MIS18A MLH1 MLH3 MSH2 NRAS ODC1 PTPN12 PTPN2 RB1 SMAD4 SNAP29 SRC STK11 TLR2	74 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF AURKB CA9 CASP3 CASP8 CBLL1 CCNB1 CDC42 CDK8 CHEK1 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 DNMT3A EGFR ERBIN EZR FADD FARP2 FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MKI67 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM PTTG1 RAB8B RRM2 SFRP2 STX17 TMOD1 UCA1 UCHL3 VCL YES1 ZNF510
Entrez ID		55014	999
HPRD ID		05013	01885
Ensembl ID		ENSG00000136874	ENSG00000039068
Uniprot IDs		P56962	A0A0U2ZQU7 B3GN61 P12830 Q9UII7
PDB IDs		4WY4 7BV4 7BV6	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL 7STZ 8H62
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mismatched DNA Binding Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Developmental Process ATP-dependent DNA Damage Sensor Activity Chiasma Regulation Of Developmental Process Apoptotic Signaling Pathway Reproductive Process Cytosol Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Mismatch Repair Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process Negative Regulation Of ERBB Signaling Pathway Guanine/thymine Mispair Binding Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Apoptotic Process Negative Regulation Of Programmed Cell Death MAPK Cascade Programmed Cell Death Cellular Response To Indole-3-methanol Focal Adhesion Mismatch Repair Complex Cell Death Regulation Of Nervous System Development Negative Regulation Of Cell Differentiation Response To Indole-3-methanol Regulation Of Cell Population Proliferation LRR Domain Binding Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding Cell Population Proliferation Nucleotide Binding Negative Regulation Of Nervous System Development Protein Kinase Activity ATP Binding Animal Organ Development Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Localization To Nucleus Anatomical Structure Morphogenesis Flotillin Complex Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Chromosome Organization Negative Regulation Of Cell Communication	Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Cytoplasm Focal Adhesion Cadherin Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Anchoring Junction Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Cell Cortex Negative Regulation Of Apoptotic Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Protein Metabolic Process Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Cycle Nucleus Positive Regulation Of Cell Motility Negative Regulation Of Cell Motility Cytosol Cytoskeleton Positive Regulation Of Locomotion ERBB Signaling Pathway Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Organization
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