STX17 and ODC1

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		STX17	ODC1
Name		syntaxin 17	ornithine decarboxylase 1
Structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Smooth Endoplasmic Reticulum Membrane HOPS Complex SNARE Complex Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Autolysosome Membrane	Cytoplasm Cytosol
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Autophagy Golgi Organization Vesicle-mediated Transport Autophagosome Membrane Docking Protein Localization To Phagophore Assembly Site Vesicle Docking Autophagosome-lysosome Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Autophagosome Maturation	Kidney Development Polyamine Metabolic Process Polyamine Biosynthetic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Putrescine Biosynthetic Process From Arginine, Via Ornithine Regulation Of Protein Catabolic Process
Pathways		COPII-mediated vesicle transport	Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines
Drugs		None	Pyridoxal phosphate Spermine Sildenafil Valproic acid Putrescine Pyridoxine phosphate N-Pyridoxyl-Glycine-5-Monophosphate L-Eflornithine N(6)-(pyridoxal phosphate)-L-lysine Geneticin Eflornithine
GWAS		Alopecia areata ( 20596022 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: ERP44	None recorded
Interacting Genes		22 interacting genes: AURKA BUB1 CDH1 CTNNA1 DLC1 EGFR KRAS MAP2K4 MIS18A MLH1 MLH3 MSH2 NRAS ODC1 PTPN12 PTPN2 RB1 SMAD4 SNAP29 SRC STK11 TLR2	17 interacting genes: BAAT CSNK2B GORASP2 HEMGN KAT5 MAP2K1 NANS OAZ1 OAZ2 RSC1A1 SSR1 STX17 TDRD7 TK1 TMOD1 TSTD2 ZNF510
Entrez ID		55014	4953
HPRD ID		05013	01324
Ensembl ID		ENSG00000136874	ENSG00000115758
Uniprot IDs		P56962	B4DXF8 P11926
PDB IDs		4WY4 7BV4 7BV6	1D7K 2ON3 2OO0 4ZGY 5BWA 7S3F 7S3G 7U6P 7U6U 9B8M 9B8N
GO Terms Enriched among Interactors		Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mismatched DNA Binding Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Developmental Process ATP-dependent DNA Damage Sensor Activity Chiasma Regulation Of Developmental Process Apoptotic Signaling Pathway Reproductive Process Cytosol Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Mismatch Repair Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process Negative Regulation Of ERBB Signaling Pathway Guanine/thymine Mispair Binding Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Apoptotic Process Negative Regulation Of Programmed Cell Death MAPK Cascade Programmed Cell Death Cellular Response To Indole-3-methanol Focal Adhesion Mismatch Repair Complex Cell Death Regulation Of Nervous System Development Negative Regulation Of Cell Differentiation Response To Indole-3-methanol Regulation Of Cell Population Proliferation LRR Domain Binding Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding Cell Population Proliferation Nucleotide Binding Negative Regulation Of Nervous System Development Protein Kinase Activity ATP Binding Animal Organ Development Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Localization To Nucleus Anatomical Structure Morphogenesis Flotillin Complex Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Chromosome Organization Negative Regulation Of Cell Communication	Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Viral Translational Frameshifting Polyamine Biosynthetic Process Polyamine Metabolic Process Negative Regulation Of Transmembrane Transport Golgi Organization Viral Process Amine Biosynthetic Process Biogenic Amine Biosynthetic Process