BRINP2 and KLHL20

Data Source: HiPPIP (Novel)

		BRINP2	KLHL20
Name		BMP/retinoic acid inducible neural specific 2	kelch like family member 20
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Dendrite Neuronal Cell Body	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	None	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Nervous System Development Central Nervous System Neuron Differentiation Multicellular Organism Growth Locomotion Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cellular Response To Retinoic Acid	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination
Pathways		None	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body composition traits ( 30026463 ) Schizophrenia ( 29483656 )	Feeling miserable ( 29500382 )
Novel Interactors		2 novel interactors: KLHL20 TBX19	1 novel interactors: BRINP2
Interacting Genes		None recorded	81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT
Entrez ID		57795	27252
HPRD ID		13891	13918
Ensembl ID		ENSG00000198797	ENSG00000076321
Uniprot IDs		Q9C0B6	Q9Y2M5
PDB IDs		Not available	5YQ4 6GY5 8CIA
GO Terms Enriched among Interactors		Protein K33-linked Ubiquitination Type II Interferon Binding	Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I