MED20 and MED18

Number of citations of the paper that reports this interaction (PMID 12584197)
12

Data Source:
HPRD (in vitro, in vivo)

		MED20	MED18
Gene Name		mediator complex subunit 20	mediator complex subunit 18
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity DNA-directed RNA Polymerase Activity Protein Binding	RNA Polymerase II Transcription Cofactor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		7 interactors: CD300C ESR1 ESR2 MED18 MED29 MED8 POLR1B	8 interactors: CAMK2B HOMEZ MED20 MED31 MED9 THOC7 TRIM39 USP49
Entrez ID		9477	54797
HPRD ID		15638	17476
Ensembl ID		ENSG00000124641	ENSG00000130772
Uniprot IDs		B3KUJ9 Q9H944	B4DJL3 Q9BUE0
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription, Initiation Transcription, DNA-templated Vagina Development Uterus Development RNA Biosynthetic Process Intracellular Estrogen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Female Genitalia Development RNA Metabolic Process Prostate Gland Epithelium Morphogenesis Prostate Gland Morphogenesis Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Genitalia Development Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Nucleologenesis Nucleobase-containing Compound Metabolic Process Ovulation Cycle Process Steroid Hormone Mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Female Gonad Development Regulation Of Gene Expression Ovulation Cycle Development Of Primary Female Sexual Characteristics Cellular Nitrogen Compound Metabolic Process Hormone-mediated Signaling Pathway Prostate Epithelial Cord Elongation Nitrogen Compound Metabolic Process Gland Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Epithelial Cell Maturation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Epithelial Cell Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Nucleolus Organization Gonad Development Development Of Primary Sexual Characteristics Female Pregnancy	RNA Metabolic Process Gene Expression Inhibitory G-protein Coupled Receptor Phosphorylation Histone H2B Conserved C-terminal Lysine Deubiquitination Activation Of Meiosis Involved In Egg Activation Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Activation Of Meiosis Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Synaptic Transmission, Cholinergic Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Viral MRNA Export From Host Cell Nucleus Nitrogen Compound Metabolic Process Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Skeletal Muscle Adaptation Regulation Of Synapse Structural Plasticity Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Dendritic Spine Morphogenesis RNA Splicing Positive Regulation Of Synapse Maturation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Meiotic Nuclear Division Histone Deubiquitination Egg Activation Regulation Of Synapse Maturation Regulation Of Protein Catabolic Process MRNA Processing Positive Regulation Of Dendritic Spine Development Intracellular Transport Of Virus Regulation Of Cellular Response To Heat Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Dendritic Spine Morphogenesis
Tagcloud ?		add cenp centromere centromeres centromeric cnp1 colocalizes defect desilencing directs dramatic fission heterochromatin incorporation kinetochore mediator mitosis ncrna ncrnas noncoding pericentromeric pol pombe rnai schizosaccharomyces segregation transcribed ultimately	aba abscisic arabidopsis associates conveys cues deregulated engender evolutionarily flowering frigida4 glutaredoxins grx480 grxs13 h5 insensitive mediator multifunctional occupancy reinforcing termination terminator thioredoxin tri trx underpinning yang1 yin yy1
Tagcloud (Difference) ?		add cenp centromere centromeres centromeric cnp1 colocalizes defect desilencing directs dramatic fission heterochromatin incorporation kinetochore mitosis ncrna ncrnas noncoding pericentromeric pol pombe rnai schizosaccharomyces segregation transcribed ultimately	aba abscisic arabidopsis associates conveys cues deregulated engender evolutionarily flowering frigida4 glutaredoxins grx480 grxs13 h5 insensitive multifunctional occupancy reinforcing termination terminator thioredoxin tri trx underpinning yang1 yin yy1
Tagcloud (Intersection) ?		mediator