PTPN4 and MAPK12

Number of citations of the paper that reports this interaction (PubMedID 27246854)
30

Data Source:
BioGRID (pull down)

		PTPN4	MAPK12
Description		protein tyrosine phosphatase non-receptor type 4	mitogen-activated protein kinase 12
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Hydrolase Activity Glutamate Receptor Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Dephosphorylation	MAPK Cascade Signal Transduction Muscle Organ Development Cellular Response To Stress Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Myoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Muscle Cell Differentiation Regulation Of Cell Cycle
Pathways		Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels	NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs		Alendronic acid	Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Lymphocyte count ( 32888494)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		13 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 VANGL2 ZZEF1	30 interacting genes: CDK1 DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		5775	6300
HPRD ID		01471	03868
Ensembl ID		ENSG00000088179	ENSG00000188130
Uniprot IDs		P29074	P53778
PDB IDs		2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0 7VZE	1CM8 4QUM 6UNA 7CGA
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Protein Localization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Metal Ion Binding Post-embryonic Forelimb Morphogenesis Chromosome, Subtelomeric Region Signal Transduction In Response To DNA Damage Regulation Of Organelle Organization Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Scaffold Protein Binding Response To Cholecystokinin Translational Elongation Translation Elongation Factor Activity Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Excitatory Postsynaptic Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Triglyceride Metabolic Process Thymidine Kinase Activity Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Cerebellar Neuron Development Directional Locomotion Acylglycerol Metabolic Process Neutral Lipid Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Protein Localization To Chromosome Signal Transduction By P53 Class Mediator Cellular Developmental Process Positive Regulation Of Chromosome Organization Kinase Binding	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity MAPK Cascade Neuromuscular Junction Intracellular Signal Transduction MAP Kinase Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Cell Polarity Protein Kinase Binding Intracellular Signaling Cassette Muscle Contraction Signal Transduction Protein Kinase Activity Receptor Localization To Synapse Receptor Clustering Protein Serine Kinase Activity Cytoplasm Cytosol Protein Localization To Synapse Muscle System Process Cellular Senescence Kinase Activity Protein Localization To Cell Junction Response To Metal Ion Calmodulin Binding Negative Regulation Of Cell Cycle Kinase Binding Postsynaptic Density Membrane Cytoplasmic Side Of Plasma Membrane Regulation Of Sodium Ion Transmembrane Transport Regulation Of Chromosome Organization NLRP1 Inflammasome Complex Assembly Phosphoprotein Phosphatase Activity Negative Regulation Of P38MAPK Cascade GMP Kinase Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Cellular Response To Growth Factor Stimulus System Process GDP Metabolic Process Regulation Of Multicellular Organismal Process Chemical Synaptic Transmission Juxtaparanode Region Of Axon Response To Growth Factor Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cytoskeletal Protein Binding Cellular Response To Potassium Ion
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