PTPN4 and GRID2

Number of citations of the paper that reports this interaction (PubMedID 10748123)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		PTPN4	GRID2
Description		protein tyrosine phosphatase non-receptor type 4	glutamate ionotropic receptor delta type subunit 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Trans-synaptic Protein Complex Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Hydrolase Activity Glutamate Receptor Binding	AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Dephosphorylation	Monoatomic Ion Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Intracellular Protein Localization Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Density Assembly Synaptic Signaling Via Neuropeptide Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly Regulation Of Presynapse Assembly
Pathways		Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels
Drugs		Alendronic acid
Diseases
GWAS		Lymphocyte count ( 32888494)	Coffee consumption ( 31046077) Intelligence (MTAG) ( 29326435) Manganese levels ( 26025379) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Obsessive-compulsive traits ( 33531474) Pancreatic beta-cell glucose sensitivity ( 32944759) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking initiation ( 33082346)
Interacting Genes		13 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 VANGL2 ZZEF1	10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4
Entrez ID		5775	2895
HPRD ID		01471	06781
Ensembl ID		ENSG00000088179	ENSG00000152208
Uniprot IDs		P29074	O43424
PDB IDs		2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0 7VZE	5KC8 5KCA
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Protein Localization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Metal Ion Binding Post-embryonic Forelimb Morphogenesis Chromosome, Subtelomeric Region Signal Transduction In Response To DNA Damage Regulation Of Organelle Organization Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Scaffold Protein Binding Response To Cholecystokinin Translational Elongation Translation Elongation Factor Activity Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Excitatory Postsynaptic Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Triglyceride Metabolic Process Thymidine Kinase Activity Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Cerebellar Neuron Development Directional Locomotion Acylglycerol Metabolic Process Neutral Lipid Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Protein Localization To Chromosome Signal Transduction By P53 Class Mediator Cellular Developmental Process Positive Regulation Of Chromosome Organization Kinase Binding	Glutamate-gated Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Density Synapse Postsynaptic Density Membrane Regulation Of Presynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Complex Receptor Clustering Glutamate Receptor Signaling Pathway Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Localization Within Membrane Glutamate Receptor Binding Postsynaptic Membrane Glutamate-gated Calcium Ion Channel Activity Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Long-term Synaptic Depression Postsynaptic Density, Intracellular Component Presynaptic Membrane Dendrite Monoatomic Ion Channel Activity Modulation Of Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Synaptic Plasticity Cell-cell Signaling Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Hippocampal Mossy Fiber To CA3 Synapse Signaling Modulation Of Excitatory Postsynaptic Potential Cell Communication Cell Projection Signaling Receptor Activity Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Excitatory Postsynaptic Potential Extracellularly Glutamate-gated Ion Channel Activity Negative Regulation Of Anion Channel Activity Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?