NXT2 and USP54

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NXT2	USP54
Description		nuclear transport factor 2 like export factor 2	ubiquitin specific peptidase 54
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear RNA Export Factor Complex Nuclear Pore Central Transport Channel Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity
	Biological Process	MRNA Export From Nucleus Nucleocytoplasmic Transport Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport	Proteolysis Protein Deubiquitination
Pathways
Drugs
Diseases
GWAS			Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		24 interacting genes: APP CCDC102B CEP63 DDIT4L GOLGA2 GOLGA6L9 IKZF3 LNX1 NXF1 NXF2 NXF2B NXF3 PKM PTPN3 RASSF10 REL SRPK1 SRPK2 SSBP3 STAT3 TCF4 TRIM23 USP54 ZNF655	89 interacting genes: ANKRD11 ANKS1A ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C CSTF2 CYSRT1 DMRT3 DOK6 DTX2 DYRK1A EIF4E2 EPM2AIP1 EXOC8 FAM124B FBXO17 FNDC3B FOXI1 GCM2 HGS HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76
Entrez ID		55916	159195
HPRD ID		02264	15641
Ensembl ID		ENSG00000101888	ENSG00000166348
Uniprot IDs		Q9NPJ8	A0A7P0T9K1 B7Z7X1 Q70EL1
PDB IDs			8C61
Enriched GO Terms of Interacting Partners?		Nuclear RNA Export Factor Complex Poly(A)+ MRNA Export From Nucleus MRNA Export From Nucleus RNA Export From Nucleus Cytoplasm Nuclear Transport Nucleocytoplasmic Transport MRNA Transport Nuclear Export RNA Transport Intracellular Transport Nucleobase-containing Compound Transport Innate Immune Response Defense Response To Symbiont Protein Serine/threonine Kinase Binding Defense Response To Other Organism Response To Other Organism Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Localization Establishment Of Localization In Cell RNA Binding Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Immune Response Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Spindle Pole Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation	Membrane Fission ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Membrane Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Multivesicular Body Assembly Lysosomal Membrane Organization Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Mitotic Metaphase Chromosome Alignment Endosome Organization Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Protein Binding Metaphase Chromosome Alignment Plasma Membrane Repair ESCRT III Complex Disassembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Release From Host Cell ESCRT Complex Disassembly Regulation Of Spindle Assembly Regulation Of Transcription By RNA Polymerase II Cytokinetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Spindle Organization Chromosome Localization Regulation Of Macromolecule Biosynthetic Process Multivesicular Body Regulation Of RNA Metabolic Process POZ Domain Binding Regulation Of Centrosome Duplication Nuclear Membrane Organization Regulation Of Primary Metabolic Process Autophagosome Maturation Autophagosome Membrane Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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