EPG5 and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		EPG5	ATF7IP
Description		ectopic P-granules 5 autophagy tethering factor	activating transcription factor 7 interacting protein
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Protein Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity
	Biological Process	Mucosal Immune Response Ubiquitin-dependent Protein Catabolic Process Nucleotide Transport Autophagy Apoptotic Process Inflammatory Response Response To Unfolded Protein Endosome To Lysosome Transport Response To Virus Gene Expression Protein Catabolic Process Intracellular Receptor Signaling Pathway Endocytic Recycling Toll-like Receptor 9 Signaling Pathway Response To Type III Interferon Innate Immune Response Photoreceptor Cell Differentiation Homeostasis Of Number Of Cells Host-mediated Modulation Of Intestinal Microbiota Composition Homeostasis Of Number Of Retina Cells Neuron Apoptotic Process Defense Response To Virus Anatomical Structure Homeostasis Inclusion Body Assembly Autophagosome Maturation Maintenance Of Protein Complex Location Protein Aggregate Center Assembly Interferon-mediated Signaling Pathway Cellular Response To DsDNA	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways			PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Kawasaki disease ( 33692975) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		2 interacting genes: ATF7IP CREBBP	71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		57724	55729
HPRD ID		11157	09811
Ensembl ID		ENSG00000152223	ENSG00000171681
Uniprot IDs		A0A8Q3SIJ2 A0A8Q3SIU6 Q9BTI0 Q9HCE0	B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		7JHX	2RPQ
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Histone H3K18 Acetyltransferase Activity Transcription Corepressor Activity N-terminal Peptidyl-lysine Acetylation Transcription Coregulator Activity Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Nuclear Body MRF Binding Peptidyl-lysine Acetylation Negative Regulation Of Transcription By RNA Polymerase I Chromatin Remodeling N-terminal Protein Amino Acid Acetylation Acetyltransferase Activity Regulation Of Cellular Response To Heat Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Organization Histone Acetyltransferase Complex Negative Regulation Of Transcription By RNA Polymerase II Protein K48-linked Deubiquitination Protein-lysine-acetyltransferase Activity Protein Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase I Tau Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Digit Morphogenesis Negative Regulation Of RNA Metabolic Process Transcription Coactivator Binding Protein Destabilization Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Energy Homeostasis Positive Regulation Of DNA Recombination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To UV Chromatin DNA Binding Regulation Of Smoothened Signaling Pathway Positive Regulation Of Double-strand Break Repair	Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus
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