MYO5B and RAB25

Number of citations of the paper that reports this interaction (PMID 11408590)
102

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYO5B	RAB25
Gene Name		myosin VB	RAB25, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Myosin Complex Cytoplasmic Vesicle Membrane Protein Complex Apical Cortex Recycling Endosome Extracellular Vesicular Exosome	Cytoplasmic Membrane-bounded Vesicle Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding
	Biological Process	Renal Water Homeostasis Water Transport Metabolic Process Protein Transport Vesicle-mediated Transport Endosome Localization Transmembrane Transport	Epithelial Cell Morphogenesis Intracellular Protein Transport Exocytosis Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial Cell Migration Pseudopodium Organization Melanosome Transport Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AMOTL2 BNIP2 COIL CXCR2 KIAA1549 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 RAB8A SMAD3 TCF4 TRIM54	13 interactors: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SMAD4 SMURF2 TGFBR1
Entrez ID		4645	57111
HPRD ID		07582	06698
Ensembl ID		ENSG00000167306	ENSG00000132698
Uniprot IDs		Q7Z7A5 Q9H6Y6 Q9ULV0	P57735
PDB IDs			2OIL 3TSO
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Vesicle Localization Exocytosis Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Organelle Localization Insulin Secretion Involved In Cellular Response To Glucose Stimulus Establishment Of Vesicle Localization Secretion By Cell Cellular Pigmentation Ras Protein Signal Transduction Secretion Positive Regulation Of Cell Migration Establishment Of Organelle Localization Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Signaling Pigmentation Regulation Of Protein Localization Regulation Of Vesicle-mediated Transport Cell Communication Protein Transport Protein Secretion Vesicle-mediated Transport Response To Glucose Establishment Of Protein Localization Chemical Homeostasis Intracellular Protein Transport Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Stimulus Positive Regulation Of Cell Development Renal Water Homeostasis Response To Carbohydrate Cellular Response To Stimulus Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Glucose Homeostasis Signal Transduction Intracellular Signal Transduction Regulation Of Cell Migration DNA-templated Transcription, Initiation Protein Localization Small GTPase Mediated Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Insulin Secretion Water Transport	Response To Transforming Growth Factor Beta BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulated Secretory Pathway Endocardial Cell Differentiation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Endothelial Cell Activation Response To Growth Factor Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Germ Cell Migration Negative Regulation Of Cell Proliferation Cellular Response To Organic Substance Regulation Of SMAD Protein Import Into Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Mesenchymal Cell Development Endocardium Development Atrioventricular Valve Morphogenesis Pharyngeal System Development Cardiocyte Differentiation Mesenchymal Cell Differentiation Atrioventricular Valve Development Protein Transport Mesoderm Development Vesicle-mediated Transport Establishment Of Protein Localization Cardiac Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Pattern Specification Process Activin Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Ameboidal-type Cell Migration Cellular Localization Renal Water Homeostasis In Utero Embryonic Development Heart Development Gastrulation Regulation Of Cellular Response To Growth Factor Stimulus Heart Valve Morphogenesis Response To Organic Substance Heart Valve Development Cell Cycle Process Mesenchyme Development
Tagcloud ?		alleles comprising disequilibrium dyslexia english enrichment explores german germany hereditary language linkage loci minor nedd4l nominal reading relevance replicated rs12606138 rs555879 rs8094327 scerri sets snp snps speaking spelling substantiate	acini acquire alpha5beta1 basement cargo clic3 com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts recycling trafficking transferred
Tagcloud (Difference) ?		alleles comprising disequilibrium dyslexia english enrichment explores german germany hereditary language linkage loci minor nedd4l nominal reading relevance replicated rs12606138 rs555879 rs8094327 scerri sets snp snps speaking spelling substantiate	acini acquire alpha5beta1 basement cargo clic3 com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts recycling trafficking transferred
Tagcloud (Intersection) ?