MYO5B and ZNHIT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYO5B	ZNHIT1
Description		myosin VB	zinc finger HIT-type containing 1
Image
GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Membrane Myosin Complex Cytoplasmic Vesicle Membrane Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome	Nucleosome Swr1 Complex Nucleus Nucleoplasm
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Renal Water Homeostasis Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport	Negative Regulation Of Transcription By RNA Polymerase II Heart Process Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of T Cell Proliferation Muscle Cell Differentiation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Transcription Initiation-coupled Chromatin Remodeling Calcium Ion Homeostasis Positive Regulation Of Transcription Initiation By RNA Polymerase II Hematopoietic Stem Cell Homeostasis Negative Regulation Of G0 To G1 Transition Positive Regulation Of Lymphoid Progenitor Cell Differentiation
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 29084231 32203549) HDL cholesterol levels ( 32203549) Large HDL particle concentration ( 29084231) Longevity (100 years and older) ( 33948810) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		23 interacting genes: AMOTL2 ATOSB BNIP2 COIL CXCR2 EFHC2 FXR1 GMCL1 KIAA1549 MEI4 MEOX2 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SHANK3 SMAD3 SMARCA2 TCF4 TRIM3 TRIM54 ZNHIT1	23 interacting genes: APP BCL6 COL8A1 CSNK2B CYSRT1 DAPP1 FHL5 GOLGA6L9 GRB7 HINFP KANK2 KRTAP10-6 KRTAP10-7 KRTAP12-2 MAPK11 MAPK14 MAPK9 MDFI MYO5B OTX2 SH2D1A TNIP1 TP53
Entrez ID		4645	10467
HPRD ID		07582	15892
Ensembl ID		ENSG00000167306	ENSG00000106400
Uniprot IDs		Q7Z7A5 Q9ULV0	O43257
PDB IDs		4J5M 4LNZ 4LWZ 4LX0	8X15 8X19 8X1C
Enriched GO Terms of Interacting Partners?		Myosin V Binding Regulation Of Long-term Neuronal Synaptic Plasticity Recycling Endosome Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Germ Cell Development G Protein Activity Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cell Projection Exocytosis Transcytosis Regulation Of Endocytic Recycling Recycling Endosome Membrane Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Amyloid-beta Clearance Epithelial Cell Morphogenesis	Positive Regulation Of Reactive Oxygen Species Metabolic Process MAP Kinase Activity Cellular Senescence Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Cell Cycle Process Stress-induced Premature Senescence NLRP1 Inflammasome Complex Assembly Positive Regulation Of Apoptotic Signaling Pathway Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Cytokine Production Identical Protein Binding Inflammatory Response Negative Regulation Of Cell Cycle Cellular Response To UV-B Regulation Of MiRNA Processing Intracellular Signaling Cassette Necroptotic Process Regulation Of Regulatory NcRNA Processing Cellular Response To Oxygen-containing Compound Protein Serine/threonine Kinase Activity Cellular Response To UV Regulation Of Inflammatory Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition MAPK Cascade DNA Damage Checkpoint Signaling Programmed Necrotic Cell Death Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cell Population Proliferation Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of DNA Replication Cellular Response To Light Stimulus P38MAPK Cascade Response To UV-B Stress-activated MAPK Cascade Positive Regulation Of Myeloid Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA-mediated Gene Silencing
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