MYO5B and KIAA1549

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		MYO5B	KIAA1549
Description		myosin VB	KIAA1549
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Membrane Myosin Complex Cytoplasmic Vesicle Membrane Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome	Plasma Membrane Cilium Membrane Photoreceptor Connecting Cilium Cell Projection
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding	Protein Binding
	Biological Process	Renal Water Homeostasis Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 29084231 32203549) HDL cholesterol levels ( 32203549) Large HDL particle concentration ( 29084231) Longevity (100 years and older) ( 33948810) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)	Heel bone mineral density ( 30598549)
Interacting Genes		23 interacting genes: AMOTL2 ATOSB BNIP2 COIL CXCR2 EFHC2 FXR1 GMCL1 KIAA1549 MEI4 MEOX2 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SHANK3 SMAD3 SMARCA2 TCF4 TRIM3 TRIM54 ZNHIT1	10 interacting genes: CADPS CDC73 DST GNE ITSN2 LGALS4 MBD5 MYO5B SOD2 ZBTB16
Entrez ID		4645	57670
HPRD ID		07582	13873
Ensembl ID		ENSG00000167306	ENSG00000122778
Uniprot IDs		Q7Z7A5 Q9ULV0	Q9HCM3
PDB IDs		4J5M 4LNZ 4LWZ 4LX0
Enriched GO Terms of Interacting Partners?		Myosin V Binding Regulation Of Long-term Neuronal Synaptic Plasticity Recycling Endosome Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Germ Cell Development G Protein Activity Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cell Projection Exocytosis Transcytosis Regulation Of Endocytic Recycling Recycling Endosome Membrane Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Amyloid-beta Clearance Epithelial Cell Morphogenesis	H Zone Antibacterial Peptide Biosynthetic Process Multicellular Organismal-level Chemical Homeostasis Response To Magnetism Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Negative Regulation Of Membrane Hyperpolarization Regulation Of Fibroblast Proliferation Superoxide Dismutase Activity Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibroblast Proliferation Erythrophore Differentiation Response To Silicon Dioxide Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Myeloid Cell Differentiation Neuronal Dense Core Vesicle Membrane Vesicle-mediated Transport In Synapse CMP-N-acetylneuraminate Metabolic Process N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity CMP-N-acetylneuraminate Biosynthetic Process Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Membrane Hyperpolarization Regulation Of Fat Cell Differentiation Detection Of Oxygen Response To L-ascorbic Acid Positive Regulation Of MRNA 3'-end Processing Hemidesmosome Assembly Galactoside Binding Response To Superoxide Regulation Of NK T Cell Differentiation Endodermal Cell Fate Commitment
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