LRRN1 and PDCD6IP

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		LRRN1	PDCD6IP
Description		leucine rich repeat neuronal 1	programmed cell death 6 interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Immunological Synapse Extracellular Region Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Extracellular Exosome Anchoring Junction Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Synapse Assembly	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Cell Division Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Extracellular Exosome Biogenesis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly
Pathways			Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Callous-unemotional behaviour ( 23874384) Fractures (paediatric) ( 32742401) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Knee osteoarthritis ( 27696742) Metabolite levels ( 23823483) Refractive error ( 32231278) Restless legs syndrome ( 29029846) Waist circumference adjusted for body mass index ( 28552196)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		2 interacting genes: PDCD6IP TRAF1	43 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 LRRN1 MAPK6 NEDD4L NEURL2 NUP155 PDCD6 PTK2B RAMP3 RNF10 RNF11 SDCBP SDCBP2 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SNCA SRC SUMO2 TAB1 TSG101 TTF2 VPS28 VPS37C WWP2 YES1
Entrez ID		57633	10015
HPRD ID		14320	06425
Ensembl ID		ENSG00000175928	ENSG00000170248
Uniprot IDs		A8K6Q2 Q6UXK5	Q8WUM4
PDB IDs			2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3
Enriched GO Terms of Interacting Partners?		Extracellular Vesicle Biogenesis Extracellular Exosome Biogenesis Positive Regulation Of Extracellular Exosome Assembly Proteinase Activated Receptor Binding Actomyosin Contractile Ring Assembly Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Extracellular Exosome Assembly Thioesterase Binding Actomyosin Maintenance Of Cell Polarity Positive Regulation Of Exosomal Secretion Cell Death Tumor Necrosis Factor Receptor Binding Programmed Cell Death Apoptotic Process Cortical Actin Cytoskeleton Organization Mitotic Cytokinetic Process Flemming Body Multivesicular Body Organization Viral Budding Regulation Of Exosomal Secretion Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Multivesicular Body Assembly Midbody Abscission Regulation Of Spindle Assembly Endoplasmic Reticulum Exit Site Protein-containing Complex Assembly Regulation Of Mitotic Spindle Organization Cortical Cytoskeleton Organization Immunological Synapse Bicellular Tight Junction Assembly Cytokinetic Process Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Protein-containing Complex Organization Tight Junction Organization Metaphase Chromosome Alignment Regulation Of Centrosome Cycle Tumor Necrosis Factor-mediated Signaling Pathway Mitotic Cytokinesis Regulation Of Membrane Permeability Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Chromosome Localization Calcium-dependent Protein Binding	Endosome Viral Budding Via Host ESCRT Complex Viral Budding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Vesicle-mediated Transport Multivesicular Body Assembly Multivesicular Body Organization Establishment Of Protein Localization Late Endosome To Vacuole Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Proteolysis Involved In Protein Catabolic Process Endocytosis Protein Transport Endosome Organization Cytoplasm Regulation Of Endocytosis Multivesicular Body Macromolecule Catabolic Process Biological Process Involved In Interaction With Host Macroautophagy Endosomal Transport Receptor-mediated Endocytosis Import Into Cell Midbody Abscission Cellular Localization Establishment Of Localization In Cell Regulation Of MAPK Cascade Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Intracellular Transport Viral Release From Host Cell Receptor Internalization Vesicle Organization Protein Metabolic Process Positive Regulation Of MAPK Cascade Viral Process Late Endosome Membrane ESCRT I Complex ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Plasma Membrane Synaptic Vesicle Endocytosis Cytokinetic Process Regulation Of Organelle Assembly
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