PITPNM2 and CPNE4

Number of citations of the paper that reports this interaction (PMID 12522145)
20

Data Source:
HPRD (in vitro, two hybrid)

		PITPNM2	CPNE4
Gene Name		phosphatidylinositol transfer protein, membrane-associated 2	copine IV
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Lipid Binding
	Biological Process	Transport Metabolic Process
Pathways
Drugs
Diseases
GWAS		Platelet counts ( 21507922)	Amyotrophic lateral sclerosis ( 22959728) Neutrophil count ( 21507922)
Protein-Protein Interactions		3 interactors: CPNE1 CPNE4 PTK2B	16 interactors: ACTB BCOR BICD1 CCDC22 CEP162 CPNE1 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 UBE2M UBE2O
Entrez ID		57605	131034
HPRD ID		08335	05017
Ensembl ID		ENSG00000090975	ENSG00000196353
Uniprot IDs		Q9BZ72 Q9UF51	Q96A23
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Activation Of Janus Kinase Activity Regulation Of Inositol Trisphosphate Biosynthetic Process Activation Of Rac GTPase Activity Regulation Of Macrophage Chemotaxis Stress Fiber Assembly Glial Cell Proliferation Mature B Cell Differentiation Involved In Immune Response Signal Complex Assembly Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Bone Mineralization Mature B Cell Differentiation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Negative Regulation Of Biomineral Tissue Development Regulation Of CGMP Biosynthetic Process Response To Immobilization Stress Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Monooxygenase Activity Oocyte Maturation Negative Regulation Of Potassium Ion Transport Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Lithium Ion Regulation Of Lymphocyte Migration Regulation Of CGMP Metabolic Process Focal Adhesion Assembly Blood Vessel Endothelial Cell Migration Positive Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Muscle Cell Apoptotic Process Bone Resorption Regulation Of Establishment Of Cell Polarity Peptidyl-tyrosine Autophosphorylation Regulation Of Nitric-oxide Synthase Activity Tumor Necrosis Factor-mediated Signaling Pathway Activation Of Rho GTPase Activity Positive Regulation Of Oxidoreductase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Membrane Potential Regulation Of Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Oocyte Development Adherens Junction Assembly Oocyte Differentiation B Cell Activation Involved In Immune Response Response To Cocaine Long-term Synaptic Potentiation Regulation Of Phosphatidylinositol 3-kinase Activity Cell-substrate Junction Assembly	Cellular Component Assembly Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Protein Heterooligomerization Golgi To Plasma Membrane Transport Intracellular Transport Protein Monoubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Actin Filament Capping Organelle Transport Along Microtubule Cell Projection Organization Regulation Of Proteinase Activated Receptor Activity Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Signal Transduction Establishment Of Localization In Cell Negative Regulation Of Tooth Mineralization Negative Regulation Of Phospholipase C Activity Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Development Negative Regulation Of Protein Complex Disassembly Transport Cell Projection Morphogenesis Vesicle-mediated Transport Minus-end-directed Organelle Transport Along Microtubule Axon Guidance Cell Part Morphogenesis Regulation Of Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Protein Depolymerization Regulation Of Organelle Organization Regulation Of Golgi Inheritance Protein Oligomerization Regulation Of Protein Complex Disassembly Specification Of Axis Polarity Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Cellular Localization Negative Regulation Of Protein Complex Assembly Microtubule-based Transport Regulation Of Vascular Smooth Muscle Contraction Common-partner SMAD Protein Phosphorylation Negative Regulation Of Odontogenesis
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