PITPNM2 and CPNE1

Number of citations of the paper that reports this interaction (PubMedID 12522145)
0

Data Source:
HPRD (in vitro)

		PITPNM2	CPNE1
Description		phosphatidylinositol transfer protein membrane associated 2	copine 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Endomembrane System Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Transporter Activity Lipid Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Receptor Tyrosine Kinase Binding Phosphatidylcholine Binding Phosphatidylinositol Binding Metal Ion Binding	Phosphatidylserine Binding Endopeptidase Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Metal Ion Binding NF-kappaB Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Phospholipid Transport Intermembrane Lipid Transfer	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Calcium Ion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension
Pathways		Synthesis of PI	Glycerophospholipid biosynthesis Neutrophil degranulation
Drugs			Theophylline
Diseases
GWAS		A body shape index ( 34021172) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Educational attainment ( 25201988) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 27863252) Menopause (age at onset) ( 26414677) Multiple sclerosis ( 31604244 24076602) Platelet count ( 21507922) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 23974872 29483656 28991256 25056061) Tourette syndrome ( 30818990) Type 2 diabetes ( 30054458) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: CPNE1 CPNE4 PTK2B	22 interacting genes: ACTB BCOR BUB3 CCDC22 CEBPA CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SNCA SORBS3 SPTBN1 STK3 UBE2M UBE2O WTAP
Entrez ID		57605	8904
HPRD ID		08335	05014
Ensembl ID		ENSG00000090975	ENSG00000214078
Uniprot IDs		A5D8U3 Q9BZ72	B0QZ18 Q99829
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Neurotransmitter Receptor Regulator Activity Response To Calcium Ion Positive Regulation Of B Cell Chemotaxis Cellular Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Activation Of Janus Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Metal Ion NMDA Selective Glutamate Receptor Complex Signal Complex Assembly Peptidyl-tyrosine Autophosphorylation Marginal Zone B Cell Differentiation Signaling Receptor Activator Activity Apical Dendrite Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Postsynaptic Density Assembly Postsynaptic Density, Intracellular Component Endothelin Receptor Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Postsynaptic Specialization Assembly Negative Regulation Of Bone Mineralization Glutamatergic Synapse Regulation Of Excitatory Synapse Assembly Negative Regulation Of DNA Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Lymphocyte Chemotaxis	Regulation Of Norepinephrine Uptake Cellular Response To Metal Ion Response To Metal Ion Transporter Regulator Activity Tau Protein Binding Regulation Of Protein Localization To Cell Periphery Protein-containing Complex Nucleus Regulation Of Organelle Organization Protein-containing Complex Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apical Protein Localization Cellular Response To Lithium Ion Magnesium Ion Binding Protein Domain Specific Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Response To Lithium Ion MAPK Cascade Regulation Of Early Endosome To Late Endosome Transport Structural Constituent Of Cytoskeleton Regulation Of Apoptotic Process Cytoskeleton Regulation Of Programmed Cell Death Nucleoplasm Regulation Of Cellular Component Organization Cortical Cytoskeleton Glutamatergic Synapse Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Receptor Localization To Synapse Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Cell Development Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Establishment Of Integrated Proviral Latency Central Nervous System Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Actin Filament Capping Negative Regulation Of Actin Filament Depolymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly
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