KLHL42 and P4HB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL42	P4HB
Description		kelch like family member 42	prolyl 4-hydroxylase subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Spindle Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Protein-disulfide Reductase Activity Isomerase Activity Thiol Oxidase Activity Enzyme Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Microtubule-based Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Insulin Processing Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Migration
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling
Drugs			Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota (functional units) ( 27694959) Height ( 31562340) Osteoarthritis (hip) ( 30664745) Refractive error ( 32231278) Resting heart rate ( 27798624) Type 2 diabetes ( 30054458)
Interacting Genes		35 interacting genes: ADD1 ANKRD33 CALCOCO2 CDCA4 CKMT2 COIL CT55 CUL3 DAZAP2 DDI1 FAM168A INCA1 KRTAP19-4 MYOG OIP5 OSTF1 P4HB PFDN5 POMC RCN3 REL SERTAD1 SERTAD3 SSX2IP STAM2 STXBP4 TRIM23 TRIM54 TTC23 UBE2E3 UBQLN1 UBQLN2 UBQLN4 USHBP1 VPS52	54 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERN1 ERO1A ERO1B ESR1 FAM20C FEZ1 FNDC3B FZD10 GARIN6 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 OGT P4HA2 P4HA3 PDE4B PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69
Entrez ID		57542	5034
HPRD ID		17237	07181
Ensembl ID		ENSG00000087448	ENSG00000185624
Uniprot IDs		B2RNT7 F5H523 Q9P2K6	A0A024R8S5 P07237
PDB IDs			1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S 7ZSC 8EOJ 8GDY
Enriched GO Terms of Interacting Partners?		Autophagosome Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein-containing Complex Disassembly	Protease Binding Identical Protein Binding Endoplasmic Reticulum Lumen Collagen Type I Trimer Intermediate Filament Cellular Response To Oxygen-containing Compound Protein Binding Extracellular Space Collagen Fibril Organization Cellular Response To Glucose Stimulus Response To Amino Acid Response To Monosaccharide Tissue Development Response To Kainic Acid Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Keratinization Cellular Response To Carbohydrate Stimulus Procollagen-proline 4-dioxygenase Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Tumor Cell Extracellular Matrix Organization Extracellular Structure Organization Response To Oxidative Stress Thiol Oxidase Activity Response To Carbohydrate Intracellular Glucose Homeostasis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Proteolysis Odontoblast Differentiation Biomineral Tissue Development Keratin Filament Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Leukocyte Mediated Cytotoxicity Cellular Response To Growth Factor Stimulus Negative Regulation Of Innate Immune Response Regulation Of Monoatomic Ion Transmembrane Transport Response To Xenobiotic Stimulus Fibrillar Collagen Trimer Positive Regulation Of Axon Regeneration Regulation Of Endothelial Cell Migration Regulation Of Lymphocyte Mediated Immunity Carbohydrate Homeostasis Response To Estradiol Glucose Homeostasis Negative Regulation Of Translational Initiation Negative Regulation Of Leukocyte Activation Regulation Of Innate Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Growth Factor Positive Regulation Of Proteolysis
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