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PTCHD2 and RASGRP2
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PTCHD2
RASGRP2
Gene Name
patched domain containing 2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Integral Component Of Membrane
Nuclear Membrane
Cytosol
Plasma Membrane
Cell Junction
Ruffle Membrane
Neuron Projection
Synapse
Molecular Function
Molecular_function
Hedgehog Receptor Activity
Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Lipid Binding
Diacylglycerol Binding
Biological Process
Smoothened Signaling Pathway
Regulation Of Lipid Transport
Cholesterol Homeostasis
Regulation Of Cell Growth
Signal Transduction
Ras Protein Signal Transduction
Blood Coagulation
Platelet Activation
Positive Regulation Of Rap GTPase Activity
Cellular Response To Calcium Ion
Pathways
G alpha (q) signalling events
Signaling by GPCR
Integrin alphaIIb beta3 signaling
Platelet Aggregation (Plug Formation)
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signaling
FCERI mediated NF-kB activation
Rap1 signalling
Gastrin-CREB signalling pathway via PKC and MAPK
Fc epsilon receptor (FCERI) signaling
Platelet activation, signaling and aggregation
Adaptive Immune System
Innate Immune System
Drugs
Diseases
GWAS
Urate levels (
21768215
)
Protein-Protein Interactions
4 interactors:
CA2
CEACAM5
MYCBP
RASGRP2
6 interactors:
APP
FAM118B
KRAS
NRAS
PTCHD2
RAP1A
Entrez ID
57540
10235
HPRD ID
13852
09278
Ensembl ID
ENSG00000204624
ENSG00000068831
Uniprot IDs
Q9P2K9
A6NDC7
Q7LDG7
PDB IDs
2MA2
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Dipeptide Transmembrane Transport
Regulation Of Chloride Transport
Positive Regulation Of Cellular PH Reduction
Response To Metal Ion
Angiotensin-activated Signaling Pathway
Negative Regulation Of Myotube Differentiation
Response To Inorganic Substance
Positive Regulation Of Synaptic Transmission, GABAergic
Negative Regulation Of Anoikis
Positive Regulation Of Bone Resorption
Cellular Response To Fluid Shear Stress
Positive Regulation Of Rap GTPase Activity
Regulation Of Anoikis
Negative Regulation Of Striated Muscle Cell Differentiation
Regulation Of Rap GTPase Activity
Regulation Of Rap Protein Signal Transduction
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Tissue Remodeling
Bicarbonate Transport
Regulation Of Bone Resorption
Regulation Of Synaptic Transmission, GABAergic
Response To Fluid Shear Stress
Response To PH
Negative Regulation Of Muscle Cell Differentiation
Regulation Of Bone Remodeling
One-carbon Metabolic Process
Regulation Of Intracellular PH
Regulation Of Cellular PH
Response To Zinc Ion
Cellular Response To Calcium Ion
Positive Regulation Of Myeloid Leukocyte Differentiation
Regulation Of Myotube Differentiation
Visual Learning
Visual Behavior
Activation Of MAPKK Activity
Positive Regulation Of Rac Protein Signal Transduction
Associative Learning
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Learning
Wound Healing
Response To Wounding
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ras Protein Signal Transduction
Neurotrophin Signaling Pathway
Learning Or Memory
Activation Of Protein Kinase Activity
Regulation Of Long-term Neuronal Synaptic Plasticity
Cognition
Regulation Of Protein Phosphorylation
Regulation Of Synaptic Transmission
Regulation Of Synaptic Transmission, GABAergic
Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Response To Light Stimulus
Positive Regulation Of Protein Metabolic Process
Epithelial Tube Branching Involved In Lung Morphogenesis
Cell Surface Receptor Signaling Pathway
Axon Guidance
Regulation Of Phosphorylation
Positive Regulation Of Ras Protein Signal Transduction
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of MAPK Cascade
Response To Radiation
Positive Regulation Of Small GTPase Mediated Signal Transduction
Single-organism Behavior
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Protein Kinase Activity
Lung Morphogenesis
Cellular Response To Organonitrogen Compound
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Generation Of Neurons
Regulation Of Cell Differentiation
Axonogenesis
Neurogenesis
Positive Regulation Of Transferase Activity
Axon Development
Cellular Response To Growth Factor Stimulus
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Tagcloud (Intersection)
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