ADGRB1 and ELMO1

Number of citations of the paper that reports this interaction (PubMedID 21930703)
39

Data Source:
BioGRID (two hybrid)

		ADGRB1	ELMO1
Description		adhesion G protein-coupled receptor B1	engulfment and cell motility 1
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Cell Junction Dendrite Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Lipopolysaccharide Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding PDZ Domain Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Immune System Process Phagocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Axonogenesis Peripheral Nervous System Development Muscle Organ Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Catabolic Process Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Innate Immune Response Regulation Of Synaptic Plasticity Defense Response To Gram-negative Bacterium Positive Regulation Of Synapse Assembly Positive Regulation Of Myoblast Fusion Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Rac Protein Signal Transduction Actin Filament-based Process Actin Cytoskeleton Organization Cell Motility Regulation Of Postsynapse Assembly
Pathways			Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Bipolar disorder x sex interaction ( 34099189)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 25920553 30572963 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 30572963) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: BAIAP2 BAIAP3 DLG1 DLG4 DRD2 ELMO1 ERBB2 GPR35 GPR37 LIN7A LRRC7 MAGI1 MAGI2 MAGI3 PATJ PDZD2 PHYHIP SNTA1 SNTB1 SNTB2 SNTG2	11 interacting genes: ADGRB1 ADGRB3 APBB1 CEBPA DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		575	9844
HPRD ID		04062	12102
Ensembl ID		ENSG00000181790	ENSG00000155849
Uniprot IDs		A0A2R8Y5M7 O14514	A4D1X5 Q92556
PDB IDs			2RQR 2VSZ 3A98 6JPP 6TGB 6TGC 7DPA 7Y4A 8JHK 8XM7 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM
Enriched GO Terms of Interacting Partners?		PDZ Domain Binding Plasma Membrane Dystrophin-associated Glycoprotein Complex Protein Localization To Synapse Bicellular Tight Junction Anchoring Junction Protein Localization To Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Cell-cell Junction Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Synapse Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein-containing Complex Localization Neuromuscular Junction Adherens Junction Cell Junction L27 Domain Binding Beta-1 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Syntrophin Complex Sarcolemma Postsynaptic Density MPP7-DLG1-LIN7 Complex Neuroligin Family Protein Binding Membrane Protein Localization To Membrane Cytoplasm Establishment Or Maintenance Of Cell Polarity GMP Kinase Activity Structural Molecule Activity Synaptic Membrane Lateral Plasma Membrane Peristalsis GDP Metabolic Process Regulation Of Sodium Ion Transport Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Muscle Contraction Regulation Of Receptor Internalization Regulation Of Behavior Intracellular Protein Localization Protein Localization To Cell Periphery Regulation Of Membrane Potential Postsynaptic Membrane Presynapse Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Myoblast Fusion Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Regulation Of Synapse Assembly Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Regulation Of Synapse Organization Phagocytosis Regulation Of Cell Shape Regulation Of Anatomical Structure Morphogenesis Endocytosis Phagocytosis, Engulfment Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Cellular Component Organization Regulation Of Postsynapse Assembly Postsynapse Membrane Invagination Regulation Of Cell Morphogenesis Import Into Cell Developmental Process GTPase Activator Activity Small GTPase-mediated Signal Transduction Cell Projection Positive Regulation Of Synapse Assembly RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Small GTPase Binding Actin Cytoskeleton Organization Cytoskeleton Response To Vitamin B2 C/EBP Complex Plasma Membrane Actin Filament-based Process Intracellular Signaling Cassette Cell Migration Regulation Of Developmental Process CHOP-C/EBP Complex Integrin-mediated Signaling Pathway Membrane Raft Polarization Regulation Of Phagocytosis Myeloid Dendritic Cell Activation Involved In Immune Response Leukocyte Migration Involved In Immune Response Positive Regulation Of Cell Junction Assembly Focal Adhesion White Fat Cell Proliferation Respiratory Burst After Phagocytosis Cell Recognition Regulation Of GTPase Activity Intracellular Signal Transduction
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