NDRG2 and CLN8

Number of citations of the paper that reports this interaction (PMID 23142642)
0

Data Source:
BioGRID (two hybrid)

		NDRG2	CLN8
Gene Name		NDRG family member 2	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Growth Cone Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Vascular Endothelial Growth Factor Production Wnt Signaling Pathway Substantia Nigra Development Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Platelet-derived Growth Factor Production	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Negative Regulation Of Transferase Activity L-glutamate Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS			Gaucher disease severity ( 22388998)
Protein-Protein Interactions		4 interactors: ATP1B1 CLN8 CTDP1 MOB2	29 interactors: ARL6IP5 BNIP3 BNIP3L C14orf1 CD9 CYB5B GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUFSP
Entrez ID		57447	2055
HPRD ID		17630	06383
Ensembl ID		ENSG00000165795	ENSG00000182372
Uniprot IDs		B4DE86 Q9UN36	Q9UBY8
PDB IDs		2XMQ 2XMR 2XMS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Calcium:sodium Antiporter Activity L-glutamate Uptake Involved In Synaptic Transmission Positive Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Export From Cell Protein Transport Into Plasma Membrane Raft Protein Localization To Plasma Membrane Raft Age-dependent Response To Oxidative Stress Sodium Ion Export From Cell Sodium Ion Export Somatic Motor Neuron Differentiation Cellular Potassium Ion Homeostasis L-glutamate Import Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Exit From Mitosis Protein Localization To Membrane Raft Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Neurotransmitter Uptake Cellular Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Membrane Repolarization Neurofilament Cytoskeleton Organization Cell Communication By Electrical Coupling Potassium Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transport Neuromuscular Process Controlling Posture Amino Acid Import Positive Regulation Of Potassium Ion Transmembrane Transport Protein Transport Within Lipid Bilayer Relaxation Of Muscle Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Sodium Ion Homeostasis Potassium Ion Import Regulation Of Potassium Ion Transmembrane Transporter Activity L-glutamate Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Positive Regulation Of ATPase Activity Photoreceptor Cell Maintenance Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Social Behavior Intermediate Filament Cytoskeleton Organization Regulation Of ATPase Activity	Mitochondrial Protein Catabolic Process Transport Membrane Organization Apoptotic Signaling Pathway Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Establishment Of Localization In Cell Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Membrane Fusion Apoptotic Process Cellular Localization Programmed Cell Death Cell Death Death Mitochondrial Transport Organelle Organization Intracellular Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Oligodendrocyte Development Substantia Nigra Development Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Neural Nucleus Development Gliogenesis Mitochondrial Membrane Organization Protein Transport Dense Core Granule Maturation Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Oligodendrocyte Differentiation Establishment Of Protein Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Stress Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Serotonin Uptake Midbrain Development Glial Cell Development Cellular Response To Hypoxia Cell Communication Cellular Response To Decreased Oxygen Levels Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Intersection) ?