RAB3GAP1 and RAB39B

Number of citations of the paper that reports this interaction (PubMedID 16923123)
0

Data Source:
BioGRID (two hybrid)

		RAB3GAP1	RAB39B
Description		RAB3 GTPase activating protein catalytic subunit 1	RAB39B, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse	Autophagosome Membrane Lysosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Neuron Projection Autolysosome Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding
	Biological Process	Brain Development Hypothalamus Development Rab Protein Signal Transduction Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly	Autophagy Regulation Of Autophagy Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Synapse Organization
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Body mass index ( 25673413) Cholesterol, total ( 20686565 24097068 25961943) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)
Interacting Genes		8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7	6 interacting genes: GOLGA2 RAB3GAP1 RUFY1 SGSM3 VPS26C ZDHHC17
Entrez ID		22930	116442
HPRD ID		16002	06703
Ensembl ID		ENSG00000115839	ENSG00000155961
Uniprot IDs		A0A8J9AUI2 B9A6J2 Q15042	Q96DA2
PDB IDs		8VYB	6S5F
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagosome Assembly Regulation Of Vacuole Organization Autolysosome Membrane Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Rab Protein Signal Transduction Protein Transport Regulation Of Macroautophagy Establishment Of Protein Localization Negative Regulation Of Macroautophagy Regulation Of Organelle Assembly Autophagy Cytoplasmic Vesicle GTPase Activity Intracellular Protein Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion GTP Binding G Protein Activity Phagocytic Vesicle Membrane Phagocytic Vesicle Negative Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Intracellular Protein Transport Positive Regulation Of Protein Lipidation Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Protein Lipidation Phagosome Acidification Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Lipoprotein Metabolic Process Small GTPase-mediated Signal Transduction Autophagosome-lysosome Fusion Phagosome-lysosome Fusion Small GTPase Binding Myosin V Binding Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle Size Vesicle Organization Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Autophagosome Assembly	Establishment Of Protein Localization Cellular Localization Endosomal Transport Small GTPase-mediated Signal Transduction Cis-Golgi Network Protein Transport Vesicle-mediated Transport Intracellular Transport Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of GTPase Activity Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Hydrolase Activity Regulation Of Vesicle-mediated Transport Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Establishment Of Localization In Cell Regulation Of GTPase Activity Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Glycosylation Intracellular Protein Localization Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Rab Protein Signal Transduction Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Protein Metabolic Process Golgi Disassembly Protein-cysteine S-stearoyltransferase Activity Intracellular Signaling Cassette Regulation Of Protein Glycosylation Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Importin-alpha Family Protein Binding Regulation Of Organelle Assembly GTPase Activator Activity Golgi Ribbon Formation Rap Protein Signal Transduction Plasma Membrane To Endosome Transport Golgi Cis Cisterna Golgi Vesicle Transport Small GTPase Binding Positive Regulation Of Glutamate Secretion Regulation Of Neurotrophin TRK Receptor Signaling Pathway Asymmetric Cell Division Positive Regulation Of Catalytic Activity Regulation Of Lipoprotein Metabolic Process Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity
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