PSME2 and DUSP23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSME2	DUSP23
Description		proteasome activator subunit 2	dual specificity phosphatase 23
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GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Endopeptidase Activator Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity
	Biological Process	Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	Dephosphorylation Cilium Assembly
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs			4-Nitrophenyl Phosphate
Diseases
GWAS		Suicide behavior ( 26079190)	Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Interacting Genes		10 interacting genes: APP CEBPA DUSP23 EPHA2 LNX1 MYOD1 NAA10 NHLH1 PSME1 UBL5	32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746
Entrez ID		5721	54935
HPRD ID		03697	07908
Ensembl ID		ENSG00000100911	ENSG00000158716
Uniprot IDs		Q86SZ7 Q9UL46	A0A140VJI5 Q9BVJ7
PDB IDs		7DR6 7DRW 7NAO 7NAP 8CXB	2IMG 4ERC
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Cell Development Molecular Function Activator Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromatin DNA Binding CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Vitamin B2 C/EBP Complex Negative Regulation Of Lymphangiogenesis Notochord Cell Development Notochord Formation Axial Mesoderm Formation Myoblast Fate Determination Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Proteasome Activator Complex Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway System Development Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Defense Response To Gram-positive Bacterium
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