PSME1 and EMD

Number of citations of the paper that reports this interaction (PMID 12755701)
17

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PSME1	EMD
Gene Name		proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	emerin
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Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Extracellular Vesicular Exosome	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Microtubule Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Endopeptidase Activator Activity	Actin Binding Protein Binding Beta-tubulin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Positive Regulation Of Endopeptidase Activity Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Mitotic Cell Cycle Muscle Contraction Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Muscle Organ Development Negative Regulation Of Catenin Import Into Nucleus Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway	Mitotic Prophase Nuclear Envelope Breakdown Depolymerisation of the Nuclear Lamina Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: AIMP2 APP ATP1B1 CDC37 CHD3 EIF6 EMD EMG1 PFDN1 PIK3R3 PSME2 RPP14 SETDB1 SMN1 TK1 TUBB4B USP22 VCL VIM	36 interactors: ABT1 ACTB ACTG2 AEN AKAP8L BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CEP70 COPS6 CREB3 CTNNBIP1 DPPA4 EFHC2 FATE1 GMCL1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 PAK7 PSME1 SH3GL2 SH3GL3 SYNE1 TRAF3IP3 TRIM42 VAV1 YTHDC1 ZNF165 ZNF232
Entrez ID		5720	2010
HPRD ID		02803	02309
Ensembl ID		ENSG00000092010	ENSG00000102119
Uniprot IDs		H0YNE3 Q06323 Q86SZ9	P50402
PDB IDs		1AVO	1JEI 2ODC 2ODG
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Cell Cycle NcRNA Metabolic Process Fetal Process Involved In Parturition 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Developmental Growth Cellular Metabolic Process Positive Regulation Of Cell Cycle Multicellular Organismal Development Platelet Degranulation Protein Folding Positive Regulation Of Calcium:sodium Antiporter Activity Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Organelle Organization Anatomical Structure Development RNA Metabolic Process Ribonucleoprotein Complex Biogenesis Developmental Cell Growth Cellular Nitrogen Compound Metabolic Process System Development Protein Stabilization Positive Regulation Of Potassium Ion Import Collateral Sprouting In Absence Of Injury Cellular Component Assembly Gene Expression Positive Regulation Of Sodium Ion Export From Cell Cellular Protein Metabolic Process Cellular Process Regulation Of Mitotic Cell Cycle Collateral Sprouting Protein Transport Into Plasma Membrane Raft Axon Midline Choice Point Recognition Positive Regulation Of Mitotic Cell Cycle Blood Coagulation Spindle Organization Developmental Process Hemostasis Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization To Plasma Membrane Raft Response To Cortisol Mature Ribosome Assembly Thymidine Metabolic Process Sodium Ion Export From Cell Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Ubiquitination	Mitotic Nuclear Envelope Reassembly Establishment Of Viral Latency Nuclear Envelope Reassembly Regulation Of DNA-templated Transcription, Initiation Nucleus Organization Apoptotic Process Mitotic Nuclear Envelope Disassembly Programmed Cell Death Cell Death Death Nuclear Envelope Disassembly Negative Regulation Of Signal Transduction Sterol Regulatory Element Binding Protein Import Into Nucleus Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Tagcloud ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 samhd1 serpin serpinb6 tymp wars	adopt aforementioned arrangements arylacetamides azabicyclo bicycles bicyclo bicyclononanone bicyclononanones carbonyl diazabicycles diazabicyclononanones dipyridyl enantiomers geometries heterocyclic isoquinolines ketocyclazocine n7 nonan oxa pharmacophoric pm3 protonated protonation semiempirical stereoisomers substituents unravel
Tagcloud (Difference) ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 samhd1 serpin serpinb6 tymp wars	adopt aforementioned arrangements arylacetamides azabicyclo bicycles bicyclo bicyclononanone bicyclononanones carbonyl diazabicycles diazabicyclononanones dipyridyl enantiomers geometries heterocyclic isoquinolines ketocyclazocine n7 nonan oxa pharmacophoric pm3 protonated protonation semiempirical stereoisomers substituents unravel
Tagcloud (Intersection) ?