PSME1 and PSME2

Number of citations of the paper that reports this interaction (PubMedID 8663520)
0

Data Source:
HPRD (in vivo, in vitro)

		PSME1	PSME2
Description		proteasome activator subunit 1	proteasome activator subunit 2
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Extracellular Exosome	Proteasome Complex Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane Extracellular Exosome
	Molecular Function	Protein Binding Endopeptidase Activator Activity	Protein Binding Identical Protein Binding Endopeptidase Activator Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Antigen Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		Copper
Diseases
GWAS			Suicide behavior ( 26079190)
Interacting Genes		23 interacting genes: AIMP2 APP ATP1B1 CDC37 CEBPA CHD3 EIF6 EMD EMG1 FXR1 FXR2 PFDN1 PIK3R3 PSME2 RPP14 SETDB1 SMN1 TK1 TTC3 TUBB4B USP22 VCL VIM	10 interacting genes: APP CEBPA DUSP23 EPHA2 LNX1 MYOD1 NAA10 NHLH1 PSME1 UBL5
Entrez ID		5720	5721
HPRD ID		02803	03697
Ensembl ID		ENSG00000092010	ENSG00000100911
Uniprot IDs		A0A0K0K1L8 Q06323 Q86SZ9	Q86SZ7 Q9UL46
PDB IDs		1AVO 7DR6 7DRW 7NAO 7NAP 8CXB	7DR6 7DRW 7NAO 7NAP 8CXB
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Neuron Projection Protein Heterodimerization Activity Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Post-transcriptional Regulation Of Gene Expression Cytoplasm Positive Regulation Of Gene Expression Costamere Cytoplasmic Ribonucleoprotein Granule Nucleolus Extracellular Vesicle Regulation Of Amyloid Fibril Formation Translation Regulator Activity Cytosol Unfolded Protein Binding Dentate Gyrus Development Positive Regulation Of Protein Metabolic Process Amyloid Fibril Formation Nucleus Positive Regulation Of Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding TMEM240-body Assembly Of Large Subunit Precursor Of Preribosome Positive Regulation Of Translation Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome RRNA (pseudouridine) Methyltransferase Activity Presynaptic Modulation Of Chemical Synaptic Transmission	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Cell Development Molecular Function Activator Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromatin DNA Binding CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Vitamin B2 C/EBP Complex Negative Regulation Of Lymphangiogenesis Notochord Cell Development Notochord Formation Axial Mesoderm Formation Myoblast Fate Determination Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Proteasome Activator Complex Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway System Development Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Defense Response To Gram-positive Bacterium
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