PSME1 and USP22

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)

		PSME1	USP22
Description		proteasome activator subunit 1	ubiquitin specific peptidase 22
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Extracellular Exosome	SAGA Complex Nucleus Nucleoplasm Cytoplasm Transcription Factor TFTC Complex
	Molecular Function	Protein Binding Endopeptidase Activator Activity	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone H4 Acetyltransferase Activity Hydrolase Activity Enzyme Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Antigen Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis Embryo Development Ending In Birth Or Egg Hatching Protein Deubiquitination Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation	HATs acetylate histones Ub-specific processing proteases
Drugs		Copper
Diseases
GWAS			Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		23 interacting genes: AIMP2 APP ATP1B1 CDC37 CEBPA CHD3 EIF6 EMD EMG1 FXR1 FXR2 PFDN1 PIK3R3 PSME2 RPP14 SETDB1 SMN1 TK1 TTC3 TUBB4B USP22 VCL VIM	17 interacting genes: BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1
Entrez ID		5720	23326
HPRD ID		02803	19411
Ensembl ID		ENSG00000092010	ENSG00000124422
Uniprot IDs		A0A0K0K1L8 Q06323 Q86SZ9	Q9UPT9
PDB IDs		1AVO 7DR6 7DRW 7NAO 7NAP 8CXB
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Neuron Projection Protein Heterodimerization Activity Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Post-transcriptional Regulation Of Gene Expression Cytoplasm Positive Regulation Of Gene Expression Costamere Cytoplasmic Ribonucleoprotein Granule Nucleolus Extracellular Vesicle Regulation Of Amyloid Fibril Formation Translation Regulator Activity Cytosol Unfolded Protein Binding Dentate Gyrus Development Positive Regulation Of Protein Metabolic Process Amyloid Fibril Formation Nucleus Positive Regulation Of Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding TMEM240-body Assembly Of Large Subunit Precursor Of Preribosome Positive Regulation Of Translation Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome RRNA (pseudouridine) Methyltransferase Activity Presynaptic Modulation Of Chemical Synaptic Transmission	Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome
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