RTN4 and CGREF1

		RTN4	CGREF1
Description		reticulon 4	cell growth regulator with EF-hand domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Membrane Cell Junction Cell Projection Neuron Projection Neuronal Cell Body Synapse Anchoring Junction Endoplasmic Reticulum Tubular Network Postsynapse Endoplasmic Reticulum Tubular Network Membrane Glutamatergic Synapse	Extracellular Region
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Blastocyst Formation Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Endoplasmic Reticulum Organization Nervous System Development Axonal Fasciculation Brain Development Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Central Nervous System Vasculogenesis Neuron Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Rac Protein Signal Transduction Cell Migration Involved In Vasculogenesis Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Modulation Of Chemical Synaptic Transmission Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Nervous System Development Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Cellular Response To Hypoxia Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Intracellular Sphingolipid Homeostasis Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Neutrophil Migration Positive Regulation Of Macrophage Migration Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Positive Regulation Of Artery Morphogenesis Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Vasculogenesis	Cell Adhesion Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle
Pathways		Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Fasting glucose ( 34074324) Lymphocyte count ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653 32902719)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left–right brain asymmetry ( 33723403) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		49 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 OGT PLEKHF2 POT1 PRR13 RAB33A RNF10 RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	2 interacting genes: AQP6 CFTR
Entrez ID		57142	10669
HPRD ID		07259	09365
Ensembl ID		ENSG00000115310	ENSG00000138028
Uniprot IDs		Q9NQC3	Q99674
PDB IDs		2G31 2JV5
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity Membrane Organization Signal Transduction G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Presynapse ERBB3:ERBB2 Complex Glutamatergic Synapse Cell Projection Morphogenesis Dendritic Cell Apoptotic Process Membrane Neuromuscular Process Neuron Differentiation Response To Epidermal Growth Factor Protein Localization To Synapse Regulation Of Synapse Organization ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Rho Protein Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Cell Junction Organization Myelin Sheath Axonogenesis ERBB Signaling Pathway Endosome Neuromuscular Junction Non-canonical Inflammasome Complex Assembly Shelterin Complex Neuronal Signal Transduction Protein Localization To Cell Junction Mitochondrion Organization Cell Junction Assembly Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Projection Morphogenesis Signaling Receptor Activity Myelination Axon Ensheathment Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade GABA-ergic Synapse Positive Regulation Of ERK1 And ERK2 Cascade Ceramide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway	Fluid Transport Water Transport Cholesterol Biosynthetic Process Sterol Biosynthetic Process Nitrate Transmembrane Transporter Activity Chloride Transmembrane Transport Odontogenesis Chloride Transport Steroid Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Delta7-sterol 5(6)-desaturase Activity Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Inorganic Anion Transmembrane Transport Cholesterol Metabolic Process Sterol Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Positive Regulation Of Anion Channel Activity C-5 Sterol Desaturase Activity Positive Regulation Of Monoatomic Anion Transport Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Positive Regulation Of Protein Localization To Endoplasmic Reticulum Endoplasmic Reticulum Membrane Positive Regulation Of Enamel Mineralization Cell Migration Involved In Vasculogenesis Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Transepithelial Water Transport Steroid Metabolic Process Regulation Of Branching Morphogenesis Of A Nerve Intracellular Sphingolipid Homeostasis Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Positive Regulation Of Tooth Mineralization Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Endoplasmic Reticulum Tubular Network Formation Alcohol Metabolic Process Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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