HLA-DPB1

Description		major histocompatibility complex, class II, DP beta 1
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GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Proliferation Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs
Diseases		Dilated cardiomyopathy (DCM)
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alanine aminotransferase levels ( 34315874) Anti-rubella virus IgG levels ( 30053915) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Aspartate aminotransferase levels ( 34315874) Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 24940741 25802187) Dermatomyositis ( 27153935) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Extranodal natural killer T-cell lymphoma (nasal type) ( 27470079) Gait speed in old age ( 28077804) Hepatitis B ( 33736632 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Monocyte count ( 32888494 27863252) Myositis ( 26291516) Nephropathy ( 21399633) Neutrophil count ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Persistent hepatitis B virus infection ( 33736632 27244555) Plantar warts ( 28928442) Primary biliary cholangitis ( 28425483) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 29534301 31243853) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe aplastic anemia ( 32004448) Sjögren's syndrome ( 28076899 24097066) Systemic sclerosis ( 21779181) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Novel Interacting Genes		1 novel interacting genes: HLA-DQA1
Interacting Genes		8 interacting genes: CD74 COPB1 HLA-DPA1 LZTS2 MEOX2 ROBO2 RTN4 TRIP6
Entrez ID		3115
HPRD ID		00832
Ensembl ID		ENSG00000223865
Uniprot IDs		H0Y7G7 I4EC15 P04440
PDB IDs		3LQZ 4P4K 4P4R 4P57 4P5K 4P5M 7T2A 7T2B 7T2C 7T2D
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex MHC Class II Protein Complex Binding Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Membrane MHC Class II Receptor Activity Antigen Processing And Presentation Trans-Golgi Network Membrane Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of Macrophage Cytokine Production Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Neutrophil Migration Plasma Membrane Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Peptide Antigen Binding Regulation Of Macrophage Cytokine Production Golgi Membrane Regulation Of Neutrophil Migration Positive Regulation Of Immune Response Neuron Recognition Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Adaptive Immune Response Cellular Component Assembly Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Primary Ureteric Bud Growth Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Lysosomal Membrane Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Immune Response
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