PSMC1 and ZBTB8A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PSMC1	ZBTB8A
Gene Name		proteasome (prosome, macropain) 26S subunit, ATPase, 1	zinc finger and BTB domain containing 8A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Membrane Proteasome Accessory Complex Cell Junction	Cellular_component Nucleus
	Molecular Function	Protein Binding ATP Binding ATPase Activity TBP-class Protein Binding Poly(A) RNA Binding	Molecular_function DNA Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Biological_process
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: APP ATXN7 CCDC85B FKBP8 JMJD1C JMJD6 KDM1A MEOX2 PAAF1 PIAS3 PSMA7 PSMC2 PSMD2 PSMD5 PSMD7 SUV39H1 TRAF6 VCP ZBTB8A	51 interactors: AEN AP1M1 AP2M1 ARMCX1 BAZ2B BYSL CCDC33 CDKL3 CEP70 DDX6 DVL2 EIF1AD EP300 FAM161A FXR2 GPATCH2L KAT5 KAT7 KIF5B KIF9 KIFC3 LMO3 LNX1 MCM10 MFAP1 MYO15B PAXIP1 PIAS2 PRKAA2 PSMC1 RAD23A RPL9 SDCBP SYT6 TNIP3 TRIM41 UBE2I WDYHV1 YES1 ZBTB24 ZBTB48 ZBTB49 ZCCHC10 ZGPAT ZMAT2 ZNF138 ZNF250 ZNF276 ZNF408 ZNF417 ZNF587
Entrez ID		5700	653121
HPRD ID		04084	18902
Ensembl ID		ENSG00000100764	ENSG00000160062
Uniprot IDs		B4DR63 P62191 Q53XL8	D3DPQ1 Q96BR9
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Protein Ubiquitination Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Proteolysis Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Protein Polyubiquitination Positive Regulation Of Ligase Activity Cellular Protein Modification Process DNA Damage Response, Signal Transduction By P53 Class Mediator Viral Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Protein Modification By Small Protein Conjugation Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Programmed Cell Death Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	RNA Biosynthetic Process Gene Expression Transcription, DNA-templated RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Viral Process Peptidyl-lysine Modification Cellular Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Process Peptidyl-amino Acid Modification DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Androgen Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Histone Modification Metabolic Process Negative Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Protein Acetylation Protein Sumoylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Acetylation Proteasomal Protein Catabolic Process Negative Regulation Of Signaling Organelle Organization Mitotic Cell Cycle Phase Transition Internal Peptidyl-lysine Acetylation Cell Cycle Phase Transition Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Acetylation
Tagcloud ?		11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc2 psmc3 psmc4 psmc5 psmc6 q13 q22 q23 s4 tbp1 tbp7	acting boxes bozf bozf1 c2h2 cdkn1a cervix competed concentrated finger fingers gc interacted kruppel oncogenesis oncoprotein p21waf paired pok poz proto proximal repress repressed sp1 speckles stimulates zinc
Tagcloud (Difference) ?		11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc2 psmc3 psmc4 psmc5 psmc6 q13 q22 q23 s4 tbp1 tbp7	acting boxes bozf bozf1 c2h2 cdkn1a cervix competed concentrated finger fingers gc interacted kruppel oncogenesis oncoprotein p21waf paired pok poz proto proximal repress repressed sp1 speckles stimulates zinc
Tagcloud (Intersection) ?