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PSMC1 and FKBP8
Number of citations of the paper that reports this interaction (PubMedID
19546213
)
78
Data Source:
BioGRID
(fluorescent resonance energy transfer)
PSMC1
FKBP8
Description
proteasome 26S subunit, ATPase 1
FKBP prolyl isomerase 8
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Mitochondrion
Mitochondrial Envelope
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Endomembrane System
Membrane
Mitochondrial Membrane
Protein-containing Complex
Molecular Function
Nucleotide Binding
RNA Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Proteasome-activating Activity
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
Calmodulin Binding
Isomerase Activity
Identical Protein Binding
Protein Folding Chaperone
Metal Ion Binding
Disordered Domain Specific Binding
Biological Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Cell Fate Specification
Negative Regulation Of Protein Phosphorylation
Protein Folding
Apoptotic Process
Signal Transduction
Smoothened Signaling Pathway
Dorsal/ventral Pattern Formation
Regulation Of Gene Expression
Dorsal/ventral Neural Tube Patterning
Neural Tube Development
BMP Signaling Pathway
Regulation Of BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intracellular Signal Transduction
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Neuron Fate Specification
Regulation Of Macromolecule Metabolic Process
Protein Localization To Mitochondrion
Regulation Of Mitophagy
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ub-specific processing proteases
Drugs
Diseases
GWAS
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Seasonality and depression (
30217971
)
Plasma parathyroid hormone levels (
30134803
)
Urinary potassium excretion (
31409800
)
Interacting Genes
39 interacting genes:
APP
ATXN7
CCDC85B
CCND3
CEBPA
CNOT7
CRK
DSCR9
FKBP8
HSPB1
JMJD1C
JMJD6
KDM1A
LINC01554
LNX1
MAGEA2
MAGEA2B
MEOX2
MORF4L1
OGT
PAAF1
PAX4
PIAS3
PRKN
PSMA7
PSMC2
PSMD2
PSMD5
PSMD7
PTGER4
STMN2
SUMO2
SUV39H1
TRAF6
UBASH3A
UBLCP1
VCP
VHL
ZBTB8A
52 interacting genes:
AQP6
ARHGEF5
ARL13B
ATP13A2
BCL2
BCL2L1
BIK
BNIPL
CD79A
CIDEB
CLCN1
CXCR2
CYB561
CYBRD1
EBP
EGFR
ELOVL4
ERBB2
ERGIC3
FAM174A
FGF14
GPR37
JAGN1
MAPK14
MTOR
OGT
PEX12
PLN
PPP3CA
PSMC1
PSMD2
RETREG3
RHBDD2
RHEB
SCN3B
SHANK3
SLC10A1
SLC10A6
SLC35A5
SLC35B1
SLC71A2
SMO
TERF1
TMEM14B
TMEM254
TMEM31
TMEM43
TMEM45B
TMEM80
TMX1
VHL
ZFPL1
Entrez ID
5700
23770
HPRD ID
04084
05327
Ensembl ID
ENSG00000100764
ENSG00000105701
Uniprot IDs
P62191
Q53XL8
B2R8G6
Q14318
PDB IDs
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
8USD
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
2AWG
2D9F
2F2D
2MF9
3EY6
5MGX
Enriched GO Terms of Interacting Partners
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Proteasome Complex
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Post-translational Protein Modification
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Nucleus
Positive Regulation Of Proteolysis
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Protein Sumoylation
Regulation Of Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Negative Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Proteasome Accessory Complex
Positive Regulation Of Protein Catabolic Process
Protein Catabolic Process
Histone Deacetylase Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Catabolic Process
Regulation Of Protein Sumoylation
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Proteolysis
Membrane
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum
Regulation Of Cellular Localization
Mitochondrial Membrane
Negative Regulation Of Catabolic Process
Regulation Of Protein Localization
Bcl-2 Family Protein Complex
Protein Binding
Transmembrane Transport
Negative Regulation Of Autophagy
Dendritic Cell Apoptotic Process
Ascorbate Homeostasis
Intracellular Signal Transduction
Regulation Of Membrane Potential
Transmembrane Monodehydroascorbate Reductase Activity
Striated Muscle Cell Development
Skeletal Muscle Fiber Development
Bile Acid:sodium Symporter Activity
Positive Regulation Of Growth
Regulation Of Protein Catabolic Process
BH3 Domain Binding
Myotube Cell Development
Regulation Of Establishment Of Protein Localization
Muscle Cell Development
Negative Regulation Of Calcium Ion Transmembrane Transport
Intracellular Signaling Cassette
Regulation Of TORC1 Signaling
Channel Activity
ERBB2-EGFR Signaling Pathway
Cell Morphogenesis
Autophagy
Negative Regulation Of Dendritic Cell Apoptotic Process
Positive Regulation Of Striated Muscle Cell Differentiation
Oligodendrocyte Differentiation
Monoatomic Ion Transport
Regulation Of Myotube Differentiation
Positive Regulation Of Establishment Of Protein Localization
Negative Regulation Of Translational Initiation
Pyrimidine Nucleotide-sugar Transmembrane Transport
Regulation Of Growth
Positive Regulation Of Translational Initiation
Mononuclear Cell Proliferation
Nucleotide-sugar Transmembrane Transport
Negative Regulation Of Calcium Ion Transport
Identical Protein Binding
Proteasomal Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Regulatory Particle
Ciliary Membrane
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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