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PSMC1 and MORF4L1
Number of citations of the paper that reports this interaction (PubMedID
30217970
)
38
Data Source:
BioGRID
(two hybrid)
PSMC1
MORF4L1
Description
proteasome 26S subunit, ATPase 1
mortality factor 4 like 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Nucleosome
Nucleus
Nucleoplasm
Nuclear Speck
NuA4 Histone Acetyltransferase Complex
Sin3-type Complex
Molecular Function
Nucleotide Binding
RNA Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Proteasome-activating Activity
Chromatin Binding
Protein Binding
Biological Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Double-strand Break Repair Via Homologous Recombination
DNA Repair
DNA Recombination
Chromatin Organization
Regulation Of DNA-templated Transcription
DNA Damage Response
Cell Population Proliferation
Regulation Of Apoptotic Process
Positive Regulation Of DNA-templated Transcription
Fibroblast Proliferation
Regulation Of Cell Cycle
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of Double-strand Break Repair
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
HATs acetylate histones
Drugs
Diseases
GWAS
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Seasonality and depression (
30217971
)
Coronary artery disease (
32469254
33020668
)
Coronary heart disease (
21378988
)
Lung adenocarcinoma (
28604730
)
Lung cancer (
28604730
31577861
)
Lung cancer in ever smokers (
28604730
)
Myocardial infarction (
33532862
)
Pulse pressure (
27841878
30578418
)
Refractive error (
32231278
)
Squamous cell lung carcinoma (
28604730
)
Interacting Genes
39 interacting genes:
APP
ATXN7
CCDC85B
CCND3
CEBPA
CNOT7
CRK
DSCR9
FKBP8
HSPB1
JMJD1C
JMJD6
KDM1A
LINC01554
LNX1
MAGEA2
MAGEA2B
MEOX2
MORF4L1
OGT
PAAF1
PAX4
PIAS3
PRKN
PSMA7
PSMC2
PSMD2
PSMD5
PSMD7
PTGER4
STMN2
SUMO2
SUV39H1
TRAF6
UBASH3A
UBLCP1
VCP
VHL
ZBTB8A
83 interacting genes:
APP
ARID3A
ARRDC3
BEND7
BEX5
BTG3
CALM1
CAMK2B
CEBPA
CEP57L1
CWC27
DMAP1
DRAP1
DSCR9
DYSF
EP300
FAM13C
FAM9B
FBXO16
FHL3
FXR2
GMCL1
GOLGA2
GOLGA6A
GSC2
H3-4
H3C1
HINFP
HMBOX1
IKZF1
KPNA2
L3MBTL3
LHX2
LMNA
LZTS2
MEOX1
MEOX2
MRFAP1
MRFAP1L1
MRGBP
MRPL12
MSL1
NAB2
NAV2
NECAB1
NKD1
NMI
PBXIP1
PCM1
PHF12
PIBF1
PICK1
PLEKHA3
PSMC1
RACGAP1
RB1
RCBTB2
REL
SH3GLB2
SYN3
TEPSIN
TEX11
TFCP2
THAP1
TLE5
TNIP1
TNNT1
TNNT2
TRIM41
TTC3
TULP3
UBP1
USO1
VPS26A
ZBTB10
ZBTB26
ZBTB43
ZBTB8B
ZBTB9
ZC3H7A
ZNF276
ZNF438
ZNF449
Entrez ID
5700
10933
HPRD ID
04084
09532
Ensembl ID
ENSG00000100764
ENSG00000185787
Uniprot IDs
P62191
Q53XL8
Q9UBU8
PDB IDs
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
8USD
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
2AQL
2EFI
2F5J
2F5K
2LKM
2N1D
6AGO
6INE
7S4A
8BPA
8C60
Enriched GO Terms of Interacting Partners
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Proteasome Complex
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Post-translational Protein Modification
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Nucleus
Positive Regulation Of Proteolysis
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Protein Sumoylation
Regulation Of Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Negative Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Proteasome Accessory Complex
Positive Regulation Of Protein Catabolic Process
Protein Catabolic Process
Histone Deacetylase Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Catabolic Process
Regulation Of Protein Sumoylation
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Proteolysis
Identical Protein Binding
Protein Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Nucleus
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Spermatogonial Cell Division
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Positive Regulation Of Macromolecule Metabolic Process
Rb-E2F Complex
Somite Specification
Regulation Of Long-term Neuronal Synaptic Plasticity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Activity
Sequence-specific DNA Binding
Transcription Coregulator Activity
Negative Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Sequence-specific Double-stranded DNA Binding
Transcription Corepressor Activity
Troponin Complex
Chromatin Organization
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Importin-alpha Family Protein Binding
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Metabolic Process
Regulation Of Skeletal Muscle Adaptation
DNA-templated Transcription
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
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