NPY4R and PYY

Number of citations of the paper that reports this interaction (PubMedID 7493937)
0

Data Source:
HPRD (in vitro)

		NPY4R	PYY
Description		neuropeptide Y receptor Y4	peptide YY
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Extracellular Region Extracellular Space
	Molecular Function	Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Peptide Hormone Binding Neuropeptide Binding	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Signaling	Neuropeptide Signaling Pathway Feeding Behavior Intestinal Epithelial Cell Differentiation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Peptide YY (3-36) Obinepitide TM30339
Diseases
GWAS			Blood protein levels ( 30072576) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Pulse pressure ( 28135244) Response to taxane treatment (paclitaxel) ( 23006423) Triglyceride levels ( 32203549)
Interacting Genes		3 interacting genes: NPY PPY PYY	6 interacting genes: MEP1B NPY1R NPY2R NPY4R NPY5R SGTA
Entrez ID		5540	5697
HPRD ID		03476	02869
Ensembl ID		ENSG00000204174	ENSG00000131096
Uniprot IDs		P50391	P10082
PDB IDs		7X9C	2DEZ 2DF0 2L60 2NA5 7RT9 7YON
Enriched GO Terms of Interacting Partners?		Neuropeptide Y Receptor Binding Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Feeding Behavior Neuropeptide Signaling Pathway Hormone Activity Intestinal Epithelial Cell Differentiation G Protein-coupled Receptor Signaling Pathway Short-day Photoperiodism Regulation Of Nerve Growth Factor Production Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Extracellular Space Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Regulation Of Eating Behavior Monocyte Activation Extracellular Region Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Adult Feeding Behavior Epithelial Cell Differentiation Positive Regulation Of Feeding Behavior Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Regulation Of Dopamine Metabolic Process Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Positive Regulation Of Behavior Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Response To Nutrient Levels Terminal Bouton Positive Regulation Of Nitric Oxide Metabolic Process Calcium Channel Regulator Activity Central Nervous System Neuron Development Negative Regulation Of Blood Pressure Regulation Of Acute Inflammatory Response Regulation Of Synaptic Vesicle Exocytosis Defense Response To Fungus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cytosolic Calcium Ion Concentration Response To Fungus Antibacterial Humoral Response Neuron Cellular Homeostasis	Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Binding Outflow Tract Morphogenesis G Protein-coupled Receptor Activity Synaptic Signaling Via Neuropeptide Cardiac Left Ventricle Morphogenesis Signaling Cell Communication Cardiac Ventricle Morphogenesis G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Neuron Projection Regulation Of Amine Transport Feeding Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Generation Of Ovulation Cycle Rhythm Meprin A Complex TRC Complex Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission, GABAergic BAT3 Complex Binding Negative Regulation Of Secretion Negative Regulation Of Glutamate Secretion Locomotory Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of ERAD Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Presynapse Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Membrane Positive Regulation Of Catecholamine Secretion Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Amino Acid Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Tail-anchored Membrane Protein Insertion Into ER Membrane Plasma Membrane Synaptic Signaling Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Nitric Oxide Mediated Signal Transduction
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