NPY5R and RNF181

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NPY5R	RNF181
Description		neuropeptide Y receptor Y5	ring finger protein 181
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection Presynapse GABA-ergic Synapse	Cytoplasm
	Molecular Function	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Neuropeptide Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Signaling Negative Regulation Of Synaptic Transmission, GABAergic Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Generation Of Ovulation Cycle Rhythm Positive Regulation Of ERK1 And ERK2 Cascade Synaptic Signaling Via Neuropeptide	Protein Ubiquitination Protein Autoubiquitination
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Peptide YY (3-36)
Diseases
GWAS			Prostate cancer ( 21743467)
Interacting Genes		4 interacting genes: NPY NUPR1 PYY RNF181	32 interacting genes: ALB BCL10 BIRC2 BTG1 CARD11 CLK4 ELL2 FGB HBA1 MCM7 MRPS6 MT1E MT1H NDUFB10 NPY5R PEG10 RBCK1 RPL5 SFMBT2 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10
Entrez ID		4889	51255
HPRD ID		03591	14236
Ensembl ID		ENSG00000164129	ENSG00000168894
Uniprot IDs		Q15761	Q9P0P0
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Feeding Behavior Neuropeptide Signaling Pathway Short-day Photoperiodism Hormone Activity Regulation Of Nerve Growth Factor Production Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Regulation Of Female Gonad Development Regulation Of Eating Behavior Monocyte Activation Negative Regulation Of Acute Inflammatory Response Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Adult Feeding Behavior Positive Regulation Of Feeding Behavior Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Autophagosome Assembly Fibroblast Apoptotic Process Regulation Of Type B Pancreatic Cell Proliferation Acetyltransferase Activator Activity Positive Regulation Of Cellular Respiration Epithelial Cell Differentiation Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Inflammatory Response Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Regulation Of Dopamine Metabolic Process Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Glycolytic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Oxidative Phosphorylation Neuronal Dense Core Vesicle Regulation Of Appetite Negative Regulation Of ATP Metabolic Process Photoperiodism Regulation Of Feeding Behavior Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Aerobic Respiration Positive Regulation Of Behavior	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Proteolysis Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Catabolic Process Regulation Of Protein Polyubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination CBM Complex Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Post-translational Protein Modification Protein Catabolic Process Regulation Of Intracellular Signal Transduction ATP Binding Transcription Coactivator Activity Canonical NF-kappaB Signal Transduction Nucleotide Binding Macromolecule Metabolic Process Proteasomal Protein Catabolic Process TORC1 Signaling Detoxification Of Copper Ion Nucleus Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex TOR Signaling Regulation Of Signal Transduction
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