NPY1R and LSM7

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		NPY1R	LSM7
Description		neuropeptide Y receptor Y1	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding Neuropeptide Receptor Activity Neuropeptide Binding	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Outflow Tract Morphogenesis Glucose Metabolic Process Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotory Behavior Feeding Behavior Regulation Of Blood Pressure Sensory Perception Of Pain Signaling Regulation Of Multicellular Organism Growth	MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs		Peptide YY (3-36)
Diseases
GWAS		Daytime nap ( 33568662) Erythrocyte cadmium concentration ( 27005419) Lung cancer ( 28604730) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)	Parkinson's disease ( 28892059)
Interacting Genes		4 interacting genes: ATP13A2 LSM7 NPY PYY	24 interacting genes: CEBPA DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26
Entrez ID		4886	51690
HPRD ID		01215	06287
Ensembl ID		ENSG00000164128	ENSG00000130332
Uniprot IDs		P25929	Q9UK45
PDB IDs		5ZBQ 7VGX 7X9A 8K6M 8K6O	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Neuropeptide Signaling Pathway Short-day Photoperiodism Feeding Behavior Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Hormone Activity Regulation Of Nerve Growth Factor Production Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Regulation Of Exocytosis Intracellular Calcium Ion Homeostasis Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Calcium Ion Homeostasis Extracellular Vesicle Biogenesis Spermine Transport P-type Ion Transporter Activity P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Lsm1-7-Pat1 Complex Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Spliceosomal Tri-snRNP Complex Polyamine Transmembrane Transport Lsm2-8 Complex Regulation Of Eating Behavior Regulation Of Chaperone-mediated Autophagy Synaptic Signaling Via Neuropeptide Cellular Response To Manganese Ion U6 SnRNP Monocyte Activation Adult Feeding Behavior Antifungal Humoral Response Positive Regulation Of Feeding Behavior ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Epithelial Cell Differentiation Response To Manganese Ion Autophagosome-lysosome Fusion	U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions Lsm1-7-Pat1 Complex MRNA Metabolic Process RNA Splicing MRNA Processing Spliceosomal Complex RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Precatalytic Spliceosome MRNA Catabolic Process Ribonucleoprotein Complex Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Catabolic Process Nucleic Acid Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex RNA Binding Catalytic Step 2 Spliceosome P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNP Nuclear MRNA Surveillance Methylosome U6 SnRNA Binding Protein-RNA Complex Assembly Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) U1 SnRNP Nucleoplasm U5 SnRNP SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Macromolecule Catabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex
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