NPY1R and NPY

Number of citations of the paper that reports this interaction (PubMedID 7559383)
0

Data Source:
HPRD (in vivo)

		NPY1R	NPY
Description		neuropeptide Y receptor Y1	neuropeptide Y
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm GABA-ergic Synapse Neuronal Dense Core Vesicle
	Molecular Function	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding Neuropeptide Receptor Activity Neuropeptide Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Outflow Tract Morphogenesis Glucose Metabolic Process Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotory Behavior Feeding Behavior Regulation Of Blood Pressure Sensory Perception Of Pain Signaling Regulation Of Multicellular Organism Growth	Response To Yeast Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Adult Feeding Behavior Positive Regulation Of Cell-substrate Adhesion Antibacterial Humoral Response Antifungal Humoral Response Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Regulation Of Nerve Growth Factor Production Monocyte Activation Innate Immune Response Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Short-day Photoperiodism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Intestinal Epithelial Cell Differentiation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Signaling Via Neuropeptide Positive Regulation Of Eating Behavior Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Synaptic Vesicle Exocytosis
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Peptide YY (3-36)	Phentermine 2-aminoisobutyric acid L-tyrosinamide
Diseases
GWAS		Daytime nap ( 33568662) Erythrocyte cadmium concentration ( 27005419) Lung cancer ( 28604730) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)	Adiponectin levels ( 33562295) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Retinitis pigmentosa ( 33514863) Vitamin D levels ( 25208829)
Interacting Genes		4 interacting genes: ATP13A2 LSM7 NPY PYY	16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2
Entrez ID		4886	4852
HPRD ID		01215	01214
Ensembl ID		ENSG00000164128	ENSG00000122585
Uniprot IDs		P25929	A4D158 P01303
PDB IDs		5ZBQ 7VGX 7X9A 8K6M 8K6O	1QFA 1RON 7RTA 7VGX 7X9A 7X9B 7YOO 8K6M 8K6N 8K6O
Enriched GO Terms of Interacting Partners?		Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Neuropeptide Signaling Pathway Short-day Photoperiodism Feeding Behavior Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Hormone Activity Regulation Of Nerve Growth Factor Production Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Regulation Of Exocytosis Intracellular Calcium Ion Homeostasis Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Calcium Ion Homeostasis Extracellular Vesicle Biogenesis Spermine Transport P-type Ion Transporter Activity P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Lsm1-7-Pat1 Complex Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Spliceosomal Tri-snRNP Complex Polyamine Transmembrane Transport Lsm2-8 Complex Regulation Of Eating Behavior Regulation Of Chaperone-mediated Autophagy Synaptic Signaling Via Neuropeptide Cellular Response To Manganese Ion U6 SnRNP Monocyte Activation Adult Feeding Behavior Antifungal Humoral Response Positive Regulation Of Feeding Behavior ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Epithelial Cell Differentiation Response To Manganese Ion Autophagosome-lysosome Fusion	Neuropeptide Signaling Pathway Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway Feeding Behavior Negative Regulation Of Transport Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity Meprin A Complex Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Regulation Of Feeding Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Signaling Negative Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Communication Regulation Of Eating Behavior Outflow Tract Morphogenesis Synaptic Signaling Via Neuropeptide Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Cardiac Left Ventricle Morphogenesis Positive Regulation Of Digestive System Process Hormone Secretion ERAD Pathway Peptide Transport Regulation Of Response To Food Hormone Transport Regulation Of Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Appetite Synaptic Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Signal Transduction Amide Transport
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