BDH2 and NFYC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BDH2	NFYC
Description		3-hydroxybutyrate dehydrogenase 2	nuclear transcription factor Y subunit gamma
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	3-hydroxybutyrate Dehydrogenase Activity Protein Binding Oxidoreductase Activity 4-oxoproline Reductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor NAD Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Beta-oxidation Siderophore Biosynthetic Process Epithelial Cell Differentiation Heme Metabolic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis of Ketone Bodies	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Pulse pressure ( 30578418) Schizophrenia ( 28991256)	Adult body size ( 32376654) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: CFTR NFYC SNCA	65 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1
Entrez ID		56898	4802
HPRD ID		07103	05633
Ensembl ID		ENSG00000164039	ENSG00000066136
Uniprot IDs		Q9BUT1	Q13952
PDB IDs		2AG5	1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Exocytosis Positive Regulation Of Anion Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Ion Transport Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Enamel Mineralization Transcription Cis-regulatory Region Binding Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Regulation Of Monoatomic Ion Transmembrane Transport Transepithelial Water Transport Positive Regulation Of Secretion By Cell CCAAT-binding Factor Complex Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Tooth Mineralization Dopamine Uptake Involved In Synaptic Transmission Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Iron(II) Ion Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Regulation Of Chaperone-mediated Autophagy Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Enzyme Binding Amelogenesis Regulation Of Monoatomic Ion Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding	Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Protein-DNA Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Sequence-specific DNA Binding Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription R-SMAD Binding Transcription Preinitiation Complex Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Transcription Factor TFIID Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Co-SMAD Binding Regulation Of MiRNA Metabolic Process
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