KCMF1 and UBE2A

Number of citations of the paper that reports this interaction (PubMedID 25582440)
50

Data Source:
BioGRID (pull down, x-ray crystallography)

		KCMF1	UBE2A
Description		potassium channel modulatory factor 1	ubiquitin conjugating enzyme E2 A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Endosome Late Endosome Cytosol Plasma Membrane Synapse Ficolin-1-rich Granule Lumen	Chromatin Nucleoplasm Lysosome Endosome Late Endosome Cytosol HULC Complex
	Molecular Function	Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cytoplasmic Translation Translational Initiation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Synaptic Signaling HRI-mediated Signaling Negative Regulation Of HRI-mediated Signaling	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cytoplasmic Translation DNA Repair Postreplication Repair Chromatin Organization Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To UV Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Mitophagy
Pathways		Neutrophil degranulation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Brain connectivity ( 23471985)
Interacting Genes		5 interacting genes: HSPB1 RGS4 UBC UBE2A UBE2D2	32 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 H2BC3 HECTD3 HLTF KCMF1 MDM2 PCNA PRKN PSMG1 RAD18 RC3H1 RNF167 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBA6 UBC UBR1 UBR3 UBR5 ZMYM2
Entrez ID		56888	7319
HPRD ID		13761	02422
Ensembl ID		ENSG00000176407	ENSG00000077721
Uniprot IDs		Q9P0J7	A0A0D9SG71 P49459
PDB IDs			6CYO 6CYR 8BTL 8IEJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Protein Kinase C Signaling Ubiquitin Binding Negative Regulation Of Glycine Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein Kinase C Inhibitor Activity Negative Regulation Of Dopamine Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Protein Kinase C Signaling Dorsal Root Ganglion Development HULC Complex Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Anterograde Axonal Protein Transport Protein Polyubiquitination Proteolysis Ubiquitin Protein Ligase Binding Regulation Of Dopamine Receptor Signaling Pathway Protein Transport Along Microtubule Contractile Muscle Fiber Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Autophagy Negative Regulation Of Amino Acid Transport Ganglion Development Protein Tag Activity	Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Cellular Response To Stress Macromolecule Catabolic Process Transferase Activity DNA Damage Response Proteolysis Catabolic Process Chromatin Organization Protein K63-linked Ubiquitination Macromolecule Metabolic Process Response To Stress Nucleoplasm PML Body Zinc Ion Binding Ubiquitin Protein Ligase Binding Chromatin Remodeling Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Transcription By RNA Polymerase II Proteasomal Protein Catabolic Process Nucleus DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Hydrogen Peroxide Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription P53 Binding Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Activity Cellular Response To Actinomycin D Ubiquitin Activating Enzyme Activity Negative Regulation Of DNA-templated Transcription
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