KCMF1 and RGS4

Number of citations of the paper that reports this interaction (PubMedID 34893540)
29

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		KCMF1	RGS4
Description		potassium channel modulatory factor 1	regulator of G protein signaling 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Endosome Late Endosome Cytosol Plasma Membrane Synapse Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex
	Molecular Function	Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding
	Biological Process	Cytoplasmic Translation Translational Initiation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Synaptic Signaling HRI-mediated Signaling Negative Regulation Of HRI-mediated Signaling	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Neutrophil degranulation	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS			Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		5 interacting genes: HSPB1 RGS4 UBC UBE2A UBE2D2	15 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 PLCB1 PTAFR UBR1
Entrez ID		56888	5999
HPRD ID		13761	03947
Ensembl ID		ENSG00000176407	ENSG00000117152
Uniprot IDs		Q9P0J7	P49798
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Protein Kinase C Signaling Ubiquitin Binding Negative Regulation Of Glycine Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein Kinase C Inhibitor Activity Negative Regulation Of Dopamine Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Protein Kinase C Signaling Dorsal Root Ganglion Development HULC Complex Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Anterograde Axonal Protein Transport Protein Polyubiquitination Proteolysis Ubiquitin Protein Ligase Binding Regulation Of Dopamine Receptor Signaling Pathway Protein Transport Along Microtubule Contractile Muscle Fiber Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Autophagy Negative Regulation Of Amino Acid Transport Ganglion Development Protein Tag Activity	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity
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