SAR1A and ALG8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SAR1A	ALG8
Description		secretion associated Ras related GTPase 1A	ALG8 alpha-1,3-glucosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPII Vesicle Coat Golgi Cisterna Membrane Endoplasmic Reticulum Exit Site	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Amino Acid Sensor Activity	Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Vesicle-mediated Transport Lipoprotein Transport COPII Vesicle Coating Membrane Organization COPII-coated Vesicle Cargo Loading Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes CDG-1h
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS			Depression in smokers ( 30219690) Femur bone mineral density x serum urate levels interaction ( 34046847) Tourette syndrome ( 30818990)
Interacting Genes		92 interacting genes: ADGRE2 AIG1 ALG8 APP AQP1 AQP10 AQP3 ASGR1 ATXN1 BCL2L2 BET1 C14orf180 C3orf52 CD53 CD81 CDS2 CEBPA CES1 CLDN19 CLDND2 CLEC7A CMTM5 CNIH1 COL4A5 CTSA CXCL16 EMP3 ERG28 FA2H FAM3C GJB2 GOLT1B GRM2 GYPA HMOX1 HMOX2 IGFBP5 JAGN1 KLHL40 LAT LHFPL5 MARCHF5 MIP MOSPD3 NAT8 NRM OLFM4 ORMDL1 ORMDL2 PEX16 PLLP PLN PLP2 PMP22 RHOT2 RMDN2 RTP2 SEC22A SELENOK SERP1 SLC30A3 SLC35A1 SLC38A7 SMIM1 SNAP47 STATH STX7 STX8 SYNGR1 TECR TMEM107 TMEM109 TMEM147 TMEM14A TMEM14C TMEM187 TMEM218 TMEM243 TMEM254 TMEM267 TMEM42 TMEM97 TRAF3 TRAM1L1 TTPA UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VTI1B	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		56681	79053
HPRD ID		07608	10480
Ensembl ID		ENSG00000079332	ENSG00000159063
Uniprot IDs		Q5SQT9 Q9NR31	A0A024R5K5 A0A7P0TA89 A0A7P0TAA8 A0A7P0Z449 A0A804G6E3 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YEE0 Q9BVK2
PDB IDs		2GAO 8DZM 8DZN 8DZO 8DZT 8E0H
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane SNAP Receptor Activity SNARE Complex Protein Binding Water Channel Activity Channel Activity Glycerol Transmembrane Transport Chloride Channel Inhibitor Activity Organelle Fusion Water Transport Membrane Organization Polyol Transmembrane Transport Cellular Localization Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Heme Oxidation Heme Oxygenase (decyclizing) Activity Presynaptic Endosome Membrane Fluid Transport Vesicle-mediated Transport Vesicle Organization Endomembrane System Immunological Synapse Membrane Docking Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Localization In Cell Compact Myelin Transport Vesicle Glycerol Channel Activity Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Vesicle Docking One-carbon Compound Transport Renal Water Absorption Urea Transmembrane Transporter Activity Gap Junction-mediated Intercellular Transport Establishment Of Protein Localization Negative Regulation Of Sphingolipid Biosynthetic Process Granulocyte Differentiation Intracellular Transport Localization Within Membrane Ankyrin-1 Complex Vesicle Fusion With Golgi Apparatus Serine Palmitoyltransferase Complex Positive Regulation Of Chemokine Production Chemical Homeostasis
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