SAR1A and CES1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SAR1A	CES1
Description		secretion associated Ras related GTPase 1A	carboxylesterase 1
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPII Vesicle Coat Golgi Cisterna Membrane Endoplasmic Reticulum Exit Site	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lipid Droplet Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Amino Acid Sensor Activity	Sterol Ester Esterase Activity Protein Binding Hydrolase Activity Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity Carboxylesterase Activity
	Biological Process	Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Vesicle-mediated Transport Lipoprotein Transport COPII Vesicle Coating Membrane Organization COPII-coated Vesicle Cargo Loading Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Lipid Metabolic Process Cholesterol Biosynthetic Process Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Lipid Catabolic Process Epithelial Cell Differentiation Cholesterol Homeostasis Reverse Cholesterol Transport Medium-chain Fatty Acid Metabolic Process Regulation Of Bile Acid Biosynthetic Process Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Bile Acid Secretion
Pathways			Metabolism of Angiotensinogen to Angiotensins Phase I - Functionalization of compounds Physiological factors Aspirin ADME
Drugs			Tacrine Meperidine Levocarnitine Dextropropoxyphene Cocaine Naloxone Diamorphine Probucol Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester Cholic Acid 4-Piperidino-Piperidine N-acetyl-alpha-neuraminic acid Thenoyltrifluoroacetone Cyclandelate Avasimibe (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
Diseases
GWAS			Response to dabigatran etexilate treatment ( 23467860)
Interacting Genes		92 interacting genes: ADGRE2 AIG1 ALG8 APP AQP1 AQP10 AQP3 ASGR1 ATXN1 BCL2L2 BET1 C14orf180 C3orf52 CD53 CD81 CDS2 CEBPA CES1 CLDN19 CLDND2 CLEC7A CMTM5 CNIH1 COL4A5 CTSA CXCL16 EMP3 ERG28 FA2H FAM3C GJB2 GOLT1B GRM2 GYPA HMOX1 HMOX2 IGFBP5 JAGN1 KLHL40 LAT LHFPL5 MARCHF5 MIP MOSPD3 NAT8 NRM OLFM4 ORMDL1 ORMDL2 PEX16 PLLP PLN PLP2 PMP22 RHOT2 RMDN2 RTP2 SEC22A SELENOK SERP1 SLC30A3 SLC35A1 SLC38A7 SMIM1 SNAP47 STATH STX7 STX8 SYNGR1 TECR TMEM107 TMEM109 TMEM147 TMEM14A TMEM14C TMEM187 TMEM218 TMEM243 TMEM254 TMEM267 TMEM42 TMEM97 TRAF3 TRAM1L1 TTPA UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VTI1B	10 interacting genes: BMPR2 CREB3 CYSRT1 GORAB GUSB KPRP PDZK1IP1 PLSCR4 SAR1A VENTX
Entrez ID		56681	1066
HPRD ID		07608	00268
Ensembl ID		ENSG00000079332	ENSG00000198848
Uniprot IDs		Q5SQT9 Q9NR31	P23141
PDB IDs		2GAO 8DZM 8DZN 8DZO 8DZT 8E0H	1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 5A7F 5A7G 5A7H 8EOR 9KWL 9KWM
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane SNAP Receptor Activity SNARE Complex Protein Binding Water Channel Activity Channel Activity Glycerol Transmembrane Transport Chloride Channel Inhibitor Activity Organelle Fusion Water Transport Membrane Organization Polyol Transmembrane Transport Cellular Localization Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Heme Oxidation Heme Oxygenase (decyclizing) Activity Presynaptic Endosome Membrane Fluid Transport Vesicle-mediated Transport Vesicle Organization Endomembrane System Immunological Synapse Membrane Docking Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Localization In Cell Compact Myelin Transport Vesicle Glycerol Channel Activity Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Vesicle Docking One-carbon Compound Transport Renal Water Absorption Urea Transmembrane Transporter Activity Gap Junction-mediated Intercellular Transport Establishment Of Protein Localization Negative Regulation Of Sphingolipid Biosynthetic Process Granulocyte Differentiation Intracellular Transport Localization Within Membrane Ankyrin-1 Complex Vesicle Fusion With Golgi Apparatus Serine Palmitoyltransferase Complex Positive Regulation Of Chemokine Production Chemical Homeostasis
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