SAR1A and TMEM109

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SAR1A	TMEM109
Description		secretion associated Ras related GTPase 1A	transmembrane protein 109
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPII Vesicle Coat Golgi Cisterna Membrane Endoplasmic Reticulum Exit Site	Nucleus Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Amino Acid Sensor Activity	Protein Binding Voltage-gated Monoatomic Cation Channel Activity
	Biological Process	Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Vesicle-mediated Transport Lipoprotein Transport COPII Vesicle Coating Membrane Organization COPII-coated Vesicle Cargo Loading Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Monoatomic Cation Transmembrane Transport
Pathways
Drugs
Diseases
GWAS
Interacting Genes		92 interacting genes: ADGRE2 AIG1 ALG8 APP AQP1 AQP10 AQP3 ASGR1 ATXN1 BCL2L2 BET1 C14orf180 C3orf52 CD53 CD81 CDS2 CEBPA CES1 CLDN19 CLDND2 CLEC7A CMTM5 CNIH1 COL4A5 CTSA CXCL16 EMP3 ERG28 FA2H FAM3C GJB2 GOLT1B GRM2 GYPA HMOX1 HMOX2 IGFBP5 JAGN1 KLHL40 LAT LHFPL5 MARCHF5 MIP MOSPD3 NAT8 NRM OLFM4 ORMDL1 ORMDL2 PEX16 PLLP PLN PLP2 PMP22 RHOT2 RMDN2 RTP2 SEC22A SELENOK SERP1 SLC30A3 SLC35A1 SLC38A7 SMIM1 SNAP47 STATH STX7 STX8 SYNGR1 TECR TMEM107 TMEM109 TMEM147 TMEM14A TMEM14C TMEM187 TMEM218 TMEM243 TMEM254 TMEM267 TMEM42 TMEM97 TRAF3 TRAM1L1 TTPA UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VTI1B	16 interacting genes: AQP2 AQP9 ERGIC3 GOLM1 GPX8 LMNA MGST3 MTIF3 PDZK1IP1 RNF170 SAR1A SLC18A2 SPINT1 STOM TMEM52B TMEM80
Entrez ID		56681	79073
HPRD ID		07608	14687
Ensembl ID		ENSG00000079332	ENSG00000110108
Uniprot IDs		Q5SQT9 Q9NR31	Q9BVC6
PDB IDs		2GAO 8DZM 8DZN 8DZO 8DZT 8E0H
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane SNAP Receptor Activity SNARE Complex Protein Binding Water Channel Activity Channel Activity Glycerol Transmembrane Transport Chloride Channel Inhibitor Activity Organelle Fusion Water Transport Membrane Organization Polyol Transmembrane Transport Cellular Localization Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Heme Oxidation Heme Oxygenase (decyclizing) Activity Presynaptic Endosome Membrane Fluid Transport Vesicle-mediated Transport Vesicle Organization Endomembrane System Immunological Synapse Membrane Docking Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Localization In Cell Compact Myelin Transport Vesicle Glycerol Channel Activity Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Vesicle Docking One-carbon Compound Transport Renal Water Absorption Urea Transmembrane Transporter Activity Gap Junction-mediated Intercellular Transport Establishment Of Protein Localization Negative Regulation Of Sphingolipid Biosynthetic Process Granulocyte Differentiation Intracellular Transport Localization Within Membrane Ankyrin-1 Complex Vesicle Fusion With Golgi Apparatus Serine Palmitoyltransferase Complex Positive Regulation Of Chemokine Production Chemical Homeostasis	Polyol Transmembrane Transport Glycerol Transmembrane Transport Amine Transport Water Channel Activity Membrane Glutathione Peroxidase Activity Water Transport Organic Hydroxy Compound Transport Fluid Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Channel Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Transport Vesicle Membrane Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Amino Acid Sensor Activity Mitochondrial Translational Initiation Cellular Response To Mercury Ion Cellular Response To Water Deprivation Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Cellular Oxidant Detoxification Histamine Uptake Serotonin:sodium:chloride Symporter Activity
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