SAR1A and STX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SAR1A	STX8
Description		secretion associated Ras related GTPase 1A	syntaxin 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPII Vesicle Coat Golgi Cisterna Membrane Endoplasmic Reticulum Exit Site	Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Plasma Membrane Endomembrane System Membrane SNARE Complex Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Amino Acid Sensor Activity	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Vesicle-mediated Transport Lipoprotein Transport COPII Vesicle Coating Membrane Organization COPII-coated Vesicle Cargo Loading Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Intracellular Protein Transport Vesicle Fusion Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Type II Interferon Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		92 interacting genes: ADGRE2 AIG1 ALG8 APP AQP1 AQP10 AQP3 ASGR1 ATXN1 BCL2L2 BET1 C14orf180 C3orf52 CD53 CD81 CDS2 CEBPA CES1 CLDN19 CLDND2 CLEC7A CMTM5 CNIH1 COL4A5 CTSA CXCL16 EMP3 ERG28 FA2H FAM3C GJB2 GOLT1B GRM2 GYPA HMOX1 HMOX2 IGFBP5 JAGN1 KLHL40 LAT LHFPL5 MARCHF5 MIP MOSPD3 NAT8 NRM OLFM4 ORMDL1 ORMDL2 PEX16 PLLP PLN PLP2 PMP22 RHOT2 RMDN2 RTP2 SEC22A SELENOK SERP1 SLC30A3 SLC35A1 SLC38A7 SMIM1 SNAP47 STATH STX7 STX8 SYNGR1 TECR TMEM107 TMEM109 TMEM147 TMEM14A TMEM14C TMEM187 TMEM218 TMEM243 TMEM254 TMEM267 TMEM42 TMEM97 TRAF3 TRAM1L1 TTPA UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VTI1B	84 interacting genes: ACVR1 AMIGO1 AQP2 AQP6 ARL13B ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SLC35H1 SSMEM1 STAR STMN4 STX1A STX2 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VPS11 VPS18 VTI1B WDR91
Entrez ID		56681	9482
HPRD ID		07608	05012
Ensembl ID		ENSG00000079332	ENSG00000170310
Uniprot IDs		Q5SQT9 Q9NR31	Q9UNK0
PDB IDs		2GAO 8DZM 8DZN 8DZO 8DZT 8E0H
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane SNAP Receptor Activity SNARE Complex Protein Binding Water Channel Activity Channel Activity Glycerol Transmembrane Transport Chloride Channel Inhibitor Activity Organelle Fusion Water Transport Membrane Organization Polyol Transmembrane Transport Cellular Localization Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Heme Oxidation Heme Oxygenase (decyclizing) Activity Presynaptic Endosome Membrane Fluid Transport Vesicle-mediated Transport Vesicle Organization Endomembrane System Immunological Synapse Membrane Docking Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Localization In Cell Compact Myelin Transport Vesicle Glycerol Channel Activity Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Vesicle Docking One-carbon Compound Transport Renal Water Absorption Urea Transmembrane Transporter Activity Gap Junction-mediated Intercellular Transport Establishment Of Protein Localization Negative Regulation Of Sphingolipid Biosynthetic Process Granulocyte Differentiation Intracellular Transport Localization Within Membrane Ankyrin-1 Complex Vesicle Fusion With Golgi Apparatus Serine Palmitoyltransferase Complex Positive Regulation Of Chemokine Production Chemical Homeostasis	Membrane Syntaxin Binding Endoplasmic Reticulum Membrane SNARE Binding Membrane Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Docking Protein Binding Vesicle Docking Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Protein Transport Organelle Fusion Chloride Channel Inhibitor Activity Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Endomembrane System SNARE Complex Disassembly Soluble NSF Attachment Protein Activity Membrane Organization Transmembrane Transport Cellular Localization Endoplasmic Reticulum Neurotransmitter Transport Neurotransmitter Reuptake Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutathione Peroxidase Activity Establishment Of Protein Localization Intracellular Transport Transforming Growth Factor Beta Receptor Activity, Type I Leukotriene-C4 Synthase Activity Protein Transport Presynaptic Active Zone Membrane Norepinephrine Uptake Neurotransmitter Uptake Plasma Membrane Golgi Vesicle Transport Activin Receptor Complex Activin Receptor Activity, Type I CORVET Complex Lysosomal Membrane Renal Water Transport Voltage-gated Potassium Channel Complex Serotonin Uptake Norepinephrine Transport Protein-containing Complex Disassembly
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