KSR2

Description		kinase suppressor of ras 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Calcium-mediated Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Body mass index ( 29273807) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Body size at age 10 ( 32376654) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Coronary artery disease ( 26343387) Daytime nap ( 33568662) Depression ( 27089181) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Hip circumference adjusted for BMI ( 28552196) Late-onset Alzheimer's disease ( 27770636) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Refractive error ( 32231278) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Type 2 diabetes ( 30718926 32499647 30297969) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		7 interacting genes: CYSRT1 KRTAP10-8 MAP2K1 MAPK1 MAPK3 PJA2 RAF1
Entrez ID		283455
HPRD ID		13952
Ensembl ID		ENSG00000171435
Uniprot IDs		Q6VAB6
PDB IDs		2Y4I 5KKR 7JUQ 7JUR 7JUS 7JUT 7JUU 7JUV 7UMB
Enriched GO Terms of Interacting Partners?		ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Schwann Cell Development Face Development ERBB2 Signaling Pathway Regulation Of Golgi Inheritance Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Trachea Formation Thymus Development Bergmann Glial Cell Differentiation Glial Cell Development ERBB Signaling Pathway Regulation Of Golgi Organization Myelination Axon Ensheathment Regulation Of Early Endosome To Late Endosome Transport Hematopoietic Or Lymphoid Organ Development Pseudopodium Animal Organ Formation Lung Morphogenesis Astrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Interleukin-34-mediated Signaling Pathway MAPK Cascade ERK1 And ERK2 Cascade Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of MAPK Cascade Gland Development Cardiac Neural Crest Cell Development Involved In Heart Development Insulin Receptor Signaling Pathway Ciliary Basal Body Outer Ear Morphogenesis Protein Serine Kinase Activity Glial Cell Differentiation Protein Serine/threonine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MAP Kinase Activity Type B Pancreatic Cell Proliferation Protein Kinase Activity Late Endosome Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuroinflammatory Response Stress-activated MAPK Cascade Epithelial Cell Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration
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