PDGFC and PLAT

Number of citations of the paper that reports this interaction (PMID 22035541)
6

Data Source:
BioGRID (enzymatic study)

		PDGFC	PLAT
Gene Name		platelet derived growth factor C	plasminogen activator, tissue
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Synapse Extracellular Vesicular Exosome
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Central Nervous System Development Embryo Development Organ Morphogenesis Positive Regulation Of DNA Replication Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Cellular Response To Amino Acid Stimulus	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Synaptic Transmission, Glutamatergic Fibrinolysis Response To Peptide Hormone Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Response To CAMP Transmembrane Transport Positive Regulation Of Ovulation Cellular Response To Dexamethasone Stimulus
Pathways			Signaling by PDGF Dissolution of Fibrin Clot Orphan transporters
Drugs			Urokinase Aminocaproic Acid Ibuprofen Iloprost 6-Amino Hexanoic Acid 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Diseases
GWAS		Fasting insulin-related traits (interaction with BMI) ( 22581228) Speech perception in dyslexia ( 19786962)
Protein-Protein Interactions		5 interactors: PDGFRA PLAT PLAU ST14 SUMO1	25 interactors: ANXA2 CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LAMA5 LRP1 LRP1B MAPK1 MAPK3 PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC
Entrez ID		56034	5327
HPRD ID		10529	01419
Ensembl ID			ENSG00000104368
Uniprot IDs		Q9NRA1	B4DN26 B4DNJ1 P00750
PDB IDs			1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Smooth Muscle Cell Migration Fibrinolysis Muscle Cell Migration Platelet-derived Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Palate Development Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Response To Wounding Cell Migration Cell Motility Positive Regulation Of Ovulation Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Protein Metabolic Process PML Body Organization Protein Localization To Nuclear Pore Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Signaling Protein Localization To Nuclear Envelope Glomerular Capillary Formation Locomotion Response To Hypoxia Plasminogen Activation Metanephric Glomerulus Vasculature Development Response To Stress Movement Of Cell Or Subcellular Component Proteolysis Luteinization Metanephric Glomerulus Development Glomerulus Morphogenesis Leydig Cell Differentiation Negative Regulation Of Platelet Activation Retina Vasculature Development In Camera-type Eye Glomerulus Vasculature Development Cellular Response To Organic Substance Cellular Response To Platelet-derived Growth Factor Stimulus Cardiac Myofibril Assembly Regulation Of Interferon-gamma-mediated Signaling Pathway Response To Platelet-derived Growth Factor Regulation Of Response To Interferon-gamma Embryonic Digestive Tract Morphogenesis	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Fibrinolysis Wound Healing Negative Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Cell Migration Regulation Of Blood Coagulation Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Wound Healing Vesicle-mediated Transport Cardiovascular System Development Regulation Of Cell Adhesion Multicellular Organismal Development Developmental Process Cell Activation System Development Anatomical Structure Development Blood Vessel Development Regulation Of Protein Metabolic Process Vasculature Development Regulation Of Vesicle-mediated Transport Regulation Of Catalytic Activity Response To Stress Exocytosis Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cellular Protein Metabolic Process Receptor-mediated Endocytosis Response To Stimulus Regulation Of Cell-substrate Adhesion Locomotion Secretion Regulation Of Peptidase Activity Extracellular Matrix Disassembly Blood Vessel Morphogenesis Regulation Of Smooth Muscle Cell-matrix Adhesion Response To External Stimulus Regulation Of Golgi Inheritance Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component
Tagcloud ?		akt1 akt3 alcoholic appearance calb3 carcinogenesis chemoprevention cirrhosis d3 dysregulation estrogenic ets1 evidenced fisher hepatocarcinogenesis hepatocellular indisputable microarray neoplastic occurrence powerful ppm prominent stages steatohepatitis tamoxifen technology threatening throughput	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Difference) ?		akt1 akt3 alcoholic appearance calb3 carcinogenesis chemoprevention cirrhosis d3 dysregulation estrogenic ets1 evidenced fisher hepatocarcinogenesis hepatocellular indisputable microarray neoplastic occurrence powerful ppm prominent stages steatohepatitis tamoxifen technology threatening throughput	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Intersection) ?