PDGFC and PDGFRA

Number of citations of the paper that reports this interaction (PMID 10806482)
95

Data Source:
HPRD (in vivo, in vitro)

		PDGFC	PDGFRA
Gene Name		platelet derived growth factor C	platelet-derived growth factor receptor, alpha polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Platelet-derived Growth Factor Binding
	Biological Process	Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Central Nervous System Development Embryo Development Organ Morphogenesis Positive Regulation Of DNA Replication Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Cellular Response To Amino Acid Stimulus	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Estrogen Metabolic Process Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Chemotaxis Cardiac Myofibril Assembly Palate Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Becaplermin Imatinib Sunitinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS		Fasting insulin-related traits (interaction with BMI) ( 22581228) Speech perception in dyslexia ( 19786962)	Corneal astigmatism ( 22144915) Corneal curvature ( 23401653 21665993) Height ( 18193045) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		5 interactors: PDGFRA PLAT PLAU ST14 SUMO1	31 interactors: CAV1 CAV3 CBL CCDC155 CRK CRKL FBXO25 GRB14 ITGAV ITGB3 JAK1 PDGFA PDGFB PDGFC PDGFRB PIK3R1 PLCG1 PTPN11 SHB SHF SLC9A3R1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B TGFBR2 ULBP2
Entrez ID		56034	5156
HPRD ID		10529	01429
Ensembl ID			ENSG00000134853
Uniprot IDs		Q9NRA1	P16234
PDB IDs			1GQ5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Smooth Muscle Cell Migration Fibrinolysis Muscle Cell Migration Platelet-derived Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Palate Development Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Response To Wounding Cell Migration Cell Motility Positive Regulation Of Ovulation Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Protein Metabolic Process PML Body Organization Protein Localization To Nuclear Pore Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Signaling Protein Localization To Nuclear Envelope Glomerular Capillary Formation Locomotion Response To Hypoxia Plasminogen Activation Metanephric Glomerulus Vasculature Development Response To Stress Movement Of Cell Or Subcellular Component Proteolysis Luteinization Metanephric Glomerulus Development Glomerulus Morphogenesis Leydig Cell Differentiation Negative Regulation Of Platelet Activation Retina Vasculature Development In Camera-type Eye Glomerulus Vasculature Development Cellular Response To Organic Substance Cellular Response To Platelet-derived Growth Factor Stimulus Cardiac Myofibril Assembly Regulation Of Interferon-gamma-mediated Signaling Pathway Response To Platelet-derived Growth Factor Regulation Of Response To Interferon-gamma Embryonic Digestive Tract Morphogenesis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signaling Regulation Of Signal Transduction Immune System Process Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Blood Coagulation Positive Regulation Of Protein Metabolic Process Hemostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune System Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Leukocyte Migration Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Protein Phosphorylation Response To Hormone Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Tagcloud ?		akt1 akt3 alcoholic appearance calb3 carcinogenesis chemoprevention cirrhosis d3 dysregulation estrogenic ets1 evidenced fisher hepatocarcinogenesis hepatocellular indisputable microarray neoplastic occurrence powerful ppm prominent stages steatohepatitis tamoxifen technology threatening throughput	address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
Tagcloud (Difference) ?		akt1 akt3 alcoholic appearance calb3 carcinogenesis chemoprevention cirrhosis d3 dysregulation estrogenic ets1 evidenced fisher hepatocarcinogenesis hepatocellular indisputable microarray neoplastic occurrence powerful ppm prominent stages steatohepatitis tamoxifen technology threatening throughput	address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
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