PDGFC and ST14

Number of citations of the paper that reports this interaction (PubMedID 22035541)
53

Data Source:
BioGRID (enzymatic study)

		PDGFC	ST14
Description		platelet derived growth factor C	ST14 transmembrane serine protease matriptase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Extracellular Exosome	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Central Nervous System Development Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Cell Migration Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Positive Regulation Of Cold-induced Thermogenesis	Neural Tube Closure Proteolysis Protein Catabolic Process Keratinocyte Differentiation Epithelial Cell Differentiation Animal Organ Development Epithelial Cell Morphogenesis Involved In Placental Branching
Pathways			Formation of the cornified envelope Formation of the cornified envelope
Drugs			Urokinase Benzamidine Camostat
Diseases			Ichthyosis with hypotrichosis
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 34074324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypospadias ( 25108383) Immature fraction of reticulocytes ( 32888494) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Major depressive disorder ( 29317602) Monocyte count ( 32888494) Motor coordination ( 34177493) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 30578418) Speech perception in dyslexia ( 19786962) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418 30224653) Triglyceride levels ( 32203549) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969)	Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		5 interacting genes: PDGFRA PLAT PLAU ST14 SUMO1	16 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF PDGFC PHB1 PLAU RAD51 RGS16 SPINT1 STK11 TGFB1
Entrez ID		56034	6768
HPRD ID		10529	06005
Ensembl ID		ENSG00000145431	ENSG00000149418
Uniprot IDs		Q9NRA1	Q9Y5Y6
PDB IDs			1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T 8G1V 8G1W
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Serine Protease Inhibitor Complex Negative Regulation Of Plasminogen Activation Plasminogen Activation Serine-type Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Wound Healing Smooth Muscle Cell Migration Serine-type Endopeptidase Activity Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Response To Wounding Fibrinolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Muscle Cell Migration Positive Regulation Of Coagulation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Zymogen Activation External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Protein Processing Regulation Of Protein Maturation Protein Metabolic Process Positive Regulation Of Wound Healing Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidase Activity Roof Of Mouth Development Platelet-derived Growth Factor Alpha-receptor Activity Coagulation Blood Coagulation Hemostasis Cell Surface Enzyme-linked Receptor Protein Signaling Pathway Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Platelet-derived Growth Factor Receptor-ligand Complex Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Proteolysis Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Epithelial Cell Morphogenesis Involved In Placental Branching	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Glycoside Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Stress Regulation Of Cell Growth Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Population Proliferation Cellular Response To Ionizing Radiation Positive Regulation Of Protein Localization Response To Radiation Positive Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Growth Negative Regulation Of Intracellular Signal Transduction Anoikis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Defense Response Positive Regulation Of MAPK Cascade
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