USP54 and ANKRD11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USP54	ANKRD11
Description		ubiquitin specific peptidase 54	ankyrin repeat domain containing 11
Image			No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity
	Biological Process	Proteolysis Protein Deubiquitination	Odontogenesis Of Dentin-containing Tooth Skeletal System Morphogenesis Head Morphogenesis Face Development Face Morphogenesis
Pathways
Drugs
Diseases
GWAS		Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Eosinophil count ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252 32888494) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		89 interacting genes: ANKRD11 ANKS1A ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C CSTF2 CYSRT1 DMRT3 DOK6 DTX2 DYRK1A EIF4E2 EPM2AIP1 EXOC8 FAM124B FBXO17 FNDC3B FOXI1 GCM2 HGS HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76	92 interacting genes: ABHD11 AGR2 ANKRD33 ARID3A ARID5A BRCC3 C18orf54 C1QTNF2 CALCA CCDC196 CCHCR1 CCN3 CDC23 CDCA7L CDR2L CEP44 CFAP68 COG4 DEPTOR FAM136A FAM221B FOLR3 FTO GOLGA2 GOLGA6L9 GPRASP3 GRIPAP1 HAUS3 HDAC3 HDAC4 HDAC5 HOMEZ HOOK2 HRAS IGFBP6 IKZF1 ITGB3BP KANK2 KRT34 LZTS2 MECOM MKRN3 MTFR1L MTUS2 MXRA8 MYF5 NAB2 NCOA1 NCOA2 NCOA3 NOTO NTAQ1 PDE4DIP PIH1D2 PLAGL2 PPARA RAC3 RCOR3 RINT1 RPH3AL RSPO4 RUBCN SERTAD3 SNRNP35 SPANXN2 SPATA2 SPMIP5 SPRY1 SRC STMN3 STRA8 SYTL3 TADA2B TFIP11 TLE5 TNNI1 TRAF2 TRIM37 TRIM54 TSPOAP1 TTC23L TXN UFC1 USH1G USP54 USP6 VDR VHL ZNF426 ZNF552 ZNF655 ZNF688
Entrez ID		159195	29123
HPRD ID		15641	12456
Ensembl ID		ENSG00000166348	ENSG00000167522
Uniprot IDs		A0A7P0T9K1 B7Z7X1 Q70EL1	Q6UB99
PDB IDs		8C61
Enriched GO Terms of Interacting Partners?		Membrane Fission ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Membrane Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Multivesicular Body Assembly Lysosomal Membrane Organization Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Mitotic Metaphase Chromosome Alignment Endosome Organization Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Protein Binding Metaphase Chromosome Alignment Plasma Membrane Repair ESCRT III Complex Disassembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Release From Host Cell ESCRT Complex Disassembly Regulation Of Spindle Assembly Regulation Of Transcription By RNA Polymerase II Cytokinetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Spindle Organization Chromosome Localization Regulation Of Macromolecule Biosynthetic Process Multivesicular Body Regulation Of RNA Metabolic Process POZ Domain Binding Regulation Of Centrosome Duplication Nuclear Membrane Organization Regulation Of Primary Metabolic Process Autophagosome Maturation Autophagosome Membrane Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Regulation Of Myotube Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Nuclear Receptor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Protein Lysine Deacetylase Activity Cellular Response To Thyroglobulin Triiodothyronine Nuclear Retinoid X Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Centrosome Cycle Histone Deacetylase Activity Vitamin D Receptor Signaling Pathway Regulation Of Muscle Cell Differentiation Protein Deubiquitination DNA-binding Transcription Activator Activity Response To Thyroglobulin Triiodothyronine Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal
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