USP54 and CHMP2B

Number of citations of the paper that reports this interaction (PubMedID 19302785)
0

Data Source:
BioGRID (pull down)

		USP54	CHMP2B
Description		ubiquitin specific peptidase 54	charged multivesicular body protein 2B
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GO Annotations	Cellular Component		Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Postsynaptic Density Membrane Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Glutamatergic Synapse Amphisome Membrane
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity	Protein Binding Protein Domain Specific Binding Cadherin Binding
	Biological Process	Proteolysis Protein Deubiquitination	Plasma Membrane Repair Autophagy Nucleus Organization Endosome Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Modulation Of Chemical Synaptic Transmission Cognition Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Neuron Cellular Homeostasis Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Modification Of Postsynaptic Structure Regulation Of Postsynapse Organization Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport ESCRT III Complex Disassembly
Pathways			Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		89 interacting genes: ANKRD11 ANKS1A ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C CSTF2 CYSRT1 DMRT3 DOK6 DTX2 DYRK1A EIF4E2 EPM2AIP1 EXOC8 FAM124B FBXO17 FNDC3B FOXI1 GCM2 HGS HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76	14 interacting genes: ATP5F1C CENPF CFTR CHMP3 DPY30 FBXO7 MALSU1 PHGDH PNMA1 SNCA TERF2IP TRAF2 USP54 USP8
Entrez ID		159195	25978
HPRD ID		15641	13174
Ensembl ID		ENSG00000166348	ENSG00000083937
Uniprot IDs		A0A7P0T9K1 B7Z7X1 Q70EL1	A0A087WW88 B2RE76 Q9UQN3
PDB IDs		8C61	2JQK
Enriched GO Terms of Interacting Partners?		Membrane Fission ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Membrane Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Multivesicular Body Assembly Lysosomal Membrane Organization Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Mitotic Metaphase Chromosome Alignment Endosome Organization Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Protein Binding Metaphase Chromosome Alignment Plasma Membrane Repair ESCRT III Complex Disassembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Release From Host Cell ESCRT Complex Disassembly Regulation Of Spindle Assembly Regulation Of Transcription By RNA Polymerase II Cytokinetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Spindle Organization Chromosome Localization Regulation Of Macromolecule Biosynthetic Process Multivesicular Body Regulation Of RNA Metabolic Process POZ Domain Binding Regulation Of Centrosome Duplication Nuclear Membrane Organization Regulation Of Primary Metabolic Process Autophagosome Maturation Autophagosome Membrane Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Organelle Localization Midbody Dynein Complex Binding Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission TORC2 Complex Disassembly K63-linked Deubiquitinase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Phosphoglycerate Dehydrogenase Activity Negative Regulation Of Mitochondrial Translation
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