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RNF114 and BMI1
Number of citations of the paper that reports this interaction (PMID
22493164
)
2
Data Source:
BioGRID
(two hybrid)
RNF114
BMI1
Gene Name
ring finger protein 114
BMI1 proto-oncogene, polycomb ring finger
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Cytoplasm
Ubiquitin Ligase Complex
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PcG Protein Complex
PRC1 Complex
Molecular Function
Zinc Ion Binding
Ligase Activity
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Sequence-specific DNA Binding
RING-like Zinc Finger Domain Binding
Biological Process
Multicellular Organismal Development
Spermatogenesis
Protein Ubiquitination
Cell Differentiation
Negative Regulation Of Transcription From RNA Polymerase II Promoter
In Utero Embryonic Development
DNA Methylation
Transcription, DNA-templated
Humoral Immune Response
Segment Specification
Brain Development
Regulation Of Gene Expression
Histone Acetylation
Histone Ubiquitination
Rostrocaudal Neural Tube Patterning
Hemopoiesis
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Immature T Cell Proliferation In Thymus
Somatic Stem Cell Division
Positive Regulation Of Fibroblast Proliferation
Embryonic Skeletal System Morphogenesis
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Oxidative Stress Induced Senescence
Cellular Senescence
Drugs
Diseases
GWAS
Psoriasis (
20953189
)
Protein-Protein Interactions
26 interactors:
AK5
BMI1
EVI2A
MAPK3
RNF38
RPSA
TRAF4
TRAF6
TRAIP
TRIM52
TRIM55
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2DNL
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2K
UBE2U
UBE2W
UEVLD
XAF1
35 interactors:
CBX6
CBX7
CBX8
CSNK2B
E2F6
FOXS1
H2AFX
HIST2H2AA3
HIST2H2AC
HIST3H3
IMMT
KAT5
KIAA1377
KMT2A
LRIF1
MAPK14
NDEL1
PCGF3
PCGF6
PHC1
PHC2
PTN
RING1
RNF114
RNF2
RRM1
SOCS2
TRIM27
TUSC3
UBE2D3
UBE2I
USP11
USP7
VPS11
ZBTB16
Entrez ID
55905
648
HPRD ID
10329
01277
Ensembl ID
ENSG00000124226
ENSG00000168283
Uniprot IDs
Q9Y508
P35226
PDB IDs
2H0D
3RPG
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Protein Modification Process
Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Toll-like Receptor Signaling Pathway
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein Catabolic Process
Activation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Innate Immune Response
Protein K63-linked Ubiquitination
Regulation Of Innate Immune Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Ligase Activity
Cellular Response To Stress
Proteolysis
Regulation Of Protein Ubiquitination
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Apoptotic Process
Cellular Response To Oxygen Levels
Programmed Cell Death
Histone Ubiquitination
Catabolic Process
Immune Response-regulating Signaling Pathway
Cell Death
Death
Protein Monoubiquitination
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Ubiquitination
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Protein Modification By Small Protein Conjugation
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Transcription, DNA-templated
Chromatin Organization
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Chromosome Organization
Chromatin Modification
Histone Ubiquitination
Cellular Macromolecule Biosynthetic Process
Cellular Protein Modification Process
Negative Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Macromolecule Biosynthetic Process
Histone Modification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Organelle Organization
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Metabolic Process
Protein Monoubiquitination
Proteasomal Protein Catabolic Process
Biosynthetic Process
Cellular Protein Metabolic Process
Regulation Of Gene Expression
Response To Ionizing Radiation
Mitotic Cell Cycle
Cell Cycle
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Histone H2A Monoubiquitination
Histone H2A Ubiquitination
Protein Metabolic Process
Negative Regulation Of Interleukin-2 Production
Histone Monoubiquitination
Tagcloud
?
activators
coimmunoprecipitate
colocalize
combs
drosophila
eed
enhancer
enx1
esc
example
extra
ezh2
homolog
homology
hpc2
hybrid
interacts
melanogaster
osteosarcoma
pcg
polycomb
progeny
repressors
screen
trithorax
trxg
unlike
z
zeste
Tagcloud (Difference)
?
activators
coimmunoprecipitate
colocalize
combs
drosophila
eed
enhancer
enx1
esc
example
extra
ezh2
homolog
homology
hpc2
hybrid
interacts
melanogaster
osteosarcoma
pcg
polycomb
progeny
repressors
screen
trithorax
trxg
unlike
z
zeste
Tagcloud (Intersection)
?