ADCY5 and ADCY2

Number of citations of the paper that reports this interaction (PMID 9268375)
24

Data Source:
HPRD (in vitro)

		ADCY5	ADCY2
Gene Name		adenylate cyclase 5	adenylate cyclase 2 (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Primary Cilium	Intracellular Cytoplasm Plasma Membrane Membrane Integral Component Of Membrane Dendrite Protein Complex Membrane Raft
	Molecular Function	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Protein Heterodimerization Activity	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Adenosine Receptor Signaling Pathway Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Neuromuscular Process Controlling Balance Transmembrane Transport Cellular Response To Glucagon Stimulus	Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Phospholipase C-mediated cascade Integration of energy metabolism Signaling by FGFR in disease Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Adrenaline,noradrenaline inhibits insulin secretion Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling	Signaling by GPCR Ca-dependent events CaM pathway Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling
Drugs
Diseases
GWAS		Birth weight ( 23202124 20372150) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22693455)	Capecitabine sensitivity ( 22864933) Visceral fat ( 22589738)
Protein-Protein Interactions		7 interactors: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2	3 interactors: ADCY1 ADCY5 GNAS
Entrez ID		111	108
HPRD ID		08973	00052
Ensembl ID		ENSG00000173175	ENSG00000078295
Uniprot IDs		B3KWA8 B7Z2C7 O95622	Q08462 Q71UM8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Phospholipase Activity Platelet Activation Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Energy Reserve Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Hydrolase Activity Response To Peptide Hormone Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Response To Peptide Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Synaptic Transmission Water Transport Histone H3-T6 Phosphorylation Wound Healing Fluid Transport Positive Regulation Of Lyase Activity Positive Regulation Of Myeloid Leukocyte Differentiation Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Response To Glucagon Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Positive Regulation Of Phospholipase C Activity Regulation Of Glucose Import Regulation Of Adenylate Cyclase Activity Positive Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Kinase Activity Positive Regulation Of CAMP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Peptide Negative Regulation Of Protein Phosphorylation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of MAP Kinase Activity	CAMP Biosynthetic Process Renal Water Homeostasis CAMP Metabolic Process Cellular Response To Glucagon Stimulus Cyclic Purine Nucleotide Metabolic Process Water Transport Fluid Transport Cyclic Nucleotide Biosynthetic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Water Homeostasis Response To Glucagon Water Homeostasis Cyclic Nucleotide Metabolic Process Renal System Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Activation Of Protein Kinase A Activity Ribonucleotide Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Cellular Response To Peptide Hormone Stimulus Ribose Phosphate Metabolic Process Cellular Response To Peptide Dopamine Receptor Signaling Pathway Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Activation Of Phospholipase C Activity Nucleotide Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Positive Regulation Of Phospholipase C Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Response To Organonitrogen Compound Chemical Homeostasis Response To Hormone Organophosphate Metabolic Process Positive Regulation Of Hydrolase Activity G-protein Coupled Receptor Signaling Pathway Neurological System Process
Tagcloud ?		acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating	acaca actn1 adni analysing cr1 describing endophenotype exploits finite gnai1 grouped initiative jointly kegg lasso neuroimaging penalised pik3cg pik3r3 prkcaandprkcb psrrr ranked ranking resampling sparse tomm40 uses voxel wise
Tagcloud (Difference) ?		acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating	acaca actn1 adni analysing cr1 describing endophenotype exploits finite gnai1 grouped initiative jointly kegg lasso neuroimaging penalised pik3cg pik3r3 prkcaandprkcb psrrr ranked ranking resampling sparse tomm40 uses voxel wise
Tagcloud (Intersection) ?