ADCY5 and ADCY2

Number of citations: 0 (PubMedID 9268375)
Data Source: HPRD (in vitro)

		ADCY5	ADCY2
Name		adenylate cyclase 5	adenylate cyclase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Cell Projection	Cytoplasm Plasma Membrane Membrane Dendrite Membrane Raft
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding Scaffold Protein Binding	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Manganese Ion Binding Metal Ion Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway CAMP Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotory Behavior Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Neuromuscular Process Controlling Balance Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Forskolin	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
GWAS		Adult body size ( 32376654 ) Apolipoprotein A1 levels ( 32203549 ) Birth weight ( 31043758 20372150 23202124 33955455 27680694 ) Body fat percentage and fasting glucose (pairwise) ( 33619380 ) Body fat percentage and type 2 diabetes (pairwise) ( 33619380 ) Body mass index ( 25673413 ) Body mass index and fasting glucose (pairwise) ( 33619380 ) Body mass index and type 2 diabetes (pairwise) ( 33619380 ) Chronic kidney disease ( 26420894 ) Chronic obstructive pulmonary disease ( 30804561 ) Chronotype ( 30696823 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Fasting blood glucose ( 25631608 22581228 20081858 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting glucose ( 34059833 ) Fasting insulin ( 34059833 ) Gestational age at birth (maternal effect) ( 28877031 ) Glycated hemoglobin levels ( 28898252 34059833 ) Glycemic traits (pleiotropy) ( 31021400 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Homeostasis model assessment of beta-cell function ( 20081858 ) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Mild age-related type 2 diabetes ( 34737425 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Obesity-related traits ( 23251661 ) Offspring birth weight ( 31043758 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) PR interval ( 32439900 ) Pulse pressure ( 30224653 ) Refractive error ( 32231278 ) Spleen volume ( 34128465 ) Total cholesterol levels ( 29083408 ) Two-hour glucose ( 34059833 ) Two-hour glucose challenge ( 20081857 ) Type 2 diabetes ( 28869590 29358691 30297969 22693455 22885922 28254843 24509480 26818947 30054458 32499647 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )	Anxiety and stress-related disorders ( 31116379 ) Atorvastatin-induced myopathy ( 31220337 ) Bipolar disorder ( 31043756 34002096 24618891 ) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468 ) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468 ) Bipolar I disorder ( 31043756 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Capecitabine sensitivity ( 22864933 ) Coffee consumption ( 31046077 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Food addiction ( 27106561 ) LDL cholesterol levels in HIV infection ( 33109212 ) Mean arterial pressure (alcohol consumption interaction) ( 24376456 ) Oropharynx cancer ( 27749845 ) Pars opercularis volume ( 31530798 ) Plasma factor VII activating protease levels ( 30070759 ) Posterior-cingulate cortex volume ( 31530798 ) Smoking status (heavy vs never) ( 26423011 ) Visceral fat ( 22589738 )
Novel Interactors		None recorded	8 novel interactors: AHRR CDH18 GCDH ISL1 NUF2 OBP2A RDH12 SLC9A3
Interacting Genes		7 interacting genes: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2	6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2
Entrez ID		111	108
HPRD ID		08973	00052
Ensembl ID		ENSG00000173175	ENSG00000078295
Uniprot IDs		A0A384P5Q5 A0A8V8TP58 B3KWA8 B7Z2C7 O95622	Q08462 Q71UM8
PDB IDs		8SL3 8SL4	Not available
GO Terms Enriched among Interactors		Response To Alcohol Regulation Of Muscle System Process Regulation Of System Process Response To Peptide Hormone Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Response To Ketone Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Response To Hormone Regulation Of Hormone Secretion Regulation Of Protein Secretion G Protein-coupled Receptor Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nucleotide Binding Cellular Response To Oxygen-containing Compound Regulation Of Striated Muscle Contraction Cellular Response To Glucagon Stimulus Renal System Process Regulation Of Protein Transport Cellular Response To Forskolin Vascular Endothelial Cell Response To Fluid Shear Stress Response To Parathyroid Hormone Response To Forskolin Guanyl Nucleotide Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Response To Glucagon Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Positive Regulation Of Cholesterol Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding Response To Laminar Fluid Shear Stress Regulation Of Muscle Contraction Cellular Response To Peptide Hormone Stimulus Regulation Of Secretion By Cell Response To Prostaglandin E Regulation Of Cellular Component Organization Regulation Of Secretion Multicellular Organismal-level Water Homeostasis Signal Transduction Positive Regulation Of Cholesterol Metabolic Process Magnesium Ion Binding Regulation Of Cholesterol Biosynthetic Process Heterotrimeric G-protein Complex Cellular Response To Fluid Shear Stress Plasma Membrane	G Protein-coupled Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Protein Transport G Protein-coupled Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid CAMP Biosynthetic Process Adenylate Cyclase Activity Response To Alcohol Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Cellular Response To Forskolin Regulation Of Secretion By Cell Response To Forskolin Regulation Of Secretion Cellular Response To Catecholamine Stimulus Phosphorus-oxygen Lyase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G-protein Beta-subunit Binding CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Response To Lipid Heterotrimeric G-protein Complex Regulation Of Biological Quality Nervous System Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Protein Localization System Process Purine-containing Compound Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glutaryl-CoA Dehydrogenase Activity Positive Regulation Of Interleukin-1 Beta Production Nucleoside Phosphate Biosynthetic Process Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Negative Regulation Of Protein Secretion Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Eosinophil Degranulation