DBNDD2 and SFRP2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		DBNDD2	SFRP2
Description		dysbindin domain containing 2	secreted frizzled related protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endoplasmic Reticulum	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding ATPase Binding	Fibronectin Binding Integrin Binding Enzyme Activator Activity Wnt-protein Binding Receptor Ligand Activity Endopeptidase Activator Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Apoptotic Process Regulation Of Signal Transduction Neurogenesis Neuron Projection Development Monoatomic Ion Homeostasis ERK1 And ERK2 Cascade	Regulation Of Cell Growth Branching Involved In Blood Vessel Morphogenesis Somitogenesis Neural Tube Closure Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Apoptotic Process Cell-cell Signaling Mesodermal Cell Fate Specification Response To Nutrient Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Cell Adhesion Mediated By Integrin Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Male Sexual Characteristics Digestive Tract Morphogenesis Stem Cell Fate Specification Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Stem Cell Division
Pathways			TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases
GWAS		Malaria ( 31844061)	Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Facial morphology ( 31763980) Macular thickness ( 30535121) Nose morphology ( 29921221 33593615) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		7 interacting genes: AGTR1 CALCOCO2 CSNK1G2 CSNK1G3 LMNA SFRP2 VIPR2	15 interacting genes: BMPR1A BUB1 CDH1 CTNNA1 DBNDD2 DCC EEF1G MLH3 PAX2 PFKM RAD54B SFRP5 SMAD4 WNT1 WNT4
Entrez ID		55861	6423
HPRD ID		12763	16041
Ensembl ID		ENSG00000244274	ENSG00000145423
Uniprot IDs		Q9BQY9	A0A140VJU3 B3KSM5 Q96HF1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Angiotensin Type I Receptor Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Dermatome Development Thermosensory Behavior Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production DNA Double-strand Break Attachment To Nuclear Envelope Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Structural Constituent Of Nuclear Lamina Sclerotome Development Wnt Signaling Pathway Involved In Somitogenesis Negative Regulation Of Embryonic Development Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Midbrain Dopaminergic Neuron Differentiation Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Regulation Of Cellular Component Organization Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Import Into Cell Regulation Of Extrinsic Apoptotic Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Cell-cell Signaling Stem Cell Fate Specification Development Of Primary Male Sexual Characteristics Signaling Convergent Extension Involved In Axis Elongation Cell Communication Potassium:chloride Symporter Activity Regulation Of Renal Sodium Excretion Negative Regulation Of Mesenchymal Cell Proliferation Mesodermal Cell Fate Specification Regulation Of Establishment Of Planar Polarity Xenophagy Positive Regulation Of Autophagosome Maturation Postsynaptic Neurotransmitter Receptor Diffusion Trapping Receptor Diffusion Trapping Regulation Of Mesodermal Cell Differentiation Development Of Primary Sexual Characteristics Ammonium Channel Activity Chloride:monoatomic Cation Symporter Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Apoptotic Signaling Pathway	Branching Involved In Ureteric Bud Morphogenesis Tube Morphogenesis Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Negative Regulation Of Neurogenesis Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Development Cellular Response To Indole-3-methanol Morphogenesis Of A Branching Epithelium Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Morphogenesis Of A Branching Structure Response To Indole-3-methanol Mesendoderm Development Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Cell Differentiation Tissue Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Flotillin Complex Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Kidney Development Axis Specification Neuron Projection Development Gamma-catenin Binding Mesonephros Development Animal Organ Morphogenesis Regionalization Gland Development Negative Regulation Of Cell Development Cardiac Conduction System Development Mesenchymal To Epithelial Transition Canonical Wnt Signaling Pathway Animal Organ Development Stem Cell Differentiation Anatomical Structure Arrangement Mesenchymal Cell Differentiation Positive Regulation Of Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Male Gonad Development Morphogenesis Of An Epithelium Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Central Nervous System Neuron Differentiation Regulation Of Neurogenesis Cell Projection Organization Gonad Development
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