DBNDD2 and VIPR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		DBNDD2	VIPR2
Description		dysbindin domain containing 2	vasoactive intestinal peptide receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endoplasmic Reticulum	Plasma Membrane Membrane
	Molecular Function	Protein Binding ATPase Binding	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Apoptotic Process Regulation Of Signal Transduction Neurogenesis Neuron Projection Development Monoatomic Ion Homeostasis ERK1 And ERK2 Cascade	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling
Pathways			G alpha (s) signalling events Glucagon-type ligand receptors
Drugs
Diseases
GWAS		Malaria ( 31844061)	Academic attainment (English) ( 33594131) Corneal astigmatism ( 30306274) Diastolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Diastolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hearing loss in noise exposure ( 33242228) Myopia (pathological) ( 23406873) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sub-foveal choroidal thickness ( 29844195)
Interacting Genes		7 interacting genes: AGTR1 CALCOCO2 CSNK1G2 CSNK1G3 LMNA SFRP2 VIPR2	6 interacting genes: ADCYAP1 APP DBNDD2 ERBIN RGS14 VIP
Entrez ID		55861	7434
HPRD ID		12763	03576
Ensembl ID		ENSG00000244274	ENSG00000106018
Uniprot IDs		Q9BQY9	P41587 X5D7Q6 X5DP12
PDB IDs			2X57 7VQX 7WBJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Angiotensin Type I Receptor Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Dermatome Development Thermosensory Behavior Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production DNA Double-strand Break Attachment To Nuclear Envelope Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Structural Constituent Of Nuclear Lamina Sclerotome Development Wnt Signaling Pathway Involved In Somitogenesis Negative Regulation Of Embryonic Development Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Midbrain Dopaminergic Neuron Differentiation Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Regulation Of Cellular Component Organization Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Import Into Cell Regulation Of Extrinsic Apoptotic Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Cell-cell Signaling Stem Cell Fate Specification Development Of Primary Male Sexual Characteristics Signaling Convergent Extension Involved In Axis Elongation Cell Communication Potassium:chloride Symporter Activity Regulation Of Renal Sodium Excretion Negative Regulation Of Mesenchymal Cell Proliferation Mesodermal Cell Fate Specification Regulation Of Establishment Of Planar Polarity Xenophagy Positive Regulation Of Autophagosome Maturation Postsynaptic Neurotransmitter Receptor Diffusion Trapping Receptor Diffusion Trapping Regulation Of Mesodermal Cell Differentiation Development Of Primary Sexual Characteristics Ammonium Channel Activity Chloride:monoatomic Cation Symporter Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of CAMP/PKA Signal Transduction Regulation Of Chemokine Production Peptide Hormone Receptor Binding Antifungal Humoral Response Response To Yeast Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Neuropeptide Hormone Activity Regulation Of Protein Kinase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Kinase Activity Regulation Of Signaling Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Neuron Projection Visual Learning Defense Response To Fungus Response To Fungus Visual Behavior Antibacterial Humoral Response Regulation Of Protein Phosphorylation Signaling Receptor Binding Signal Transduction Peptide Hormone Secretion Positive Regulation Of Chemokine Production Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Pituitary Adenylate Cyclase Activating Polypeptide Activity Peptide Secretion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Epinephrine Secretion Negative Regulation Of Kinase Activity Zygote Asymmetric Cell Division Negative Regulation Of Macromolecule Metabolic Process Neuron Projection Development Regulation Of Biological Quality Defense Response To Gram-negative Bacterium Hormone Secretion
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