CYP4F2 and THAP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYP4F2	THAP4
Description		cytochrome P450 family 4 subfamily F member 2	THAP domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity Arachidonate Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity 20-hydroxy-leukotriene B4 Omega Oxidase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Long-chain Fatty Acid Omega-hydroxylase Activity	DNA Binding Protein Binding Zinc Ion Binding Isomerase Activity Heme Binding Identical Protein Binding Metal Ion Binding Peroxynitrite Isomerase Activity Nitric Oxide Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Xenobiotic Metabolic Process Blood Coagulation Regulation Of Blood Pressure Fatty Acid Omega-oxidation Arachidonate Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway	Tyrosine Metabolic Process Nitrate Metabolic Process
Pathways		Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Circulating phylloquinone levels ( 25411281) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 19300499 20833655)	Brain structure ( 20171287) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Platelet count ( 32888494) Prostate cancer ( 23535732) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		35 interacting genes: AQP6 CPLX4 CREB3 CREB3L1 DNAJC1 EBP ELOVL4 ERGIC3 FAM210B FCER1G GJA8 HSD17B13 JAGN1 LEPROTL1 MMD MTIF3 MUC1 PGRMC2 PLEKHO1 REEP2 REEP4 RETREG3 SCN3B SDHAF2 SLC10A6 SLC17A8 SLC19A3 SLC2A13 THAP4 TLCD4 TM4SF19 TMEM51 TMEM82 TMX2 UBE2I	43 interacting genes: AGTRAP AIG1 AMD1 ANKRD46 APP BSND CACNG1 CD81 CLCA4 CMTM5 CMTM7 COL4A5 CPNE2 CTSA CYP4F2 DGAT2L6 FKBP7 GIMAP1 GPR37L1 IGFBP5 LAT LCOR LPAR3 MAL2 MAPK6 MOB4 MS4A1 NDRG4 PLP2 RMDN2 RTP2 SCAMP1 SLC30A8 SYP TMEM107 TMEM60 TMEM86A TMEM86B TNFRSF10D TPD52 TRIM54 TTPA YIPF6
Entrez ID		8529	51078
HPRD ID		05112	11630
Ensembl ID		ENSG00000186115	ENSG00000176946
Uniprot IDs		P78329	Q8WY91
PDB IDs			3IA8
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Nuclear Membrane Reassembly Mitotic Nuclear Membrane Reassembly Nuclear Membrane Organization Membrane Assembly Organic Hydroxy Compound Transport	Membrane Alkenylglycerophosphocholine Hydrolase Activity Vitamin E Metabolic Process
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